Drug-Drug:
- Additive hypotension with other antihypertensives .
- NSAIDs and selective COX-2 inhibitors may blunt the antihypertensive effect and ↑ the risk of renal dysfunction.
- Excessive hypotension may occur with concurrent use of diuretics.
- ↑risk of hyperkalemia with concurrent use of potassium supplements, potassium-containing salt substitutes, or potassium-sparing diuretics.
- ↑risk of hyperkalemia, renal dysfunction, hypotension, and syncope with concurrent use of ACE inhibitors or aliskiren; avoid concurrent use with aliskiren in patients with diabetes or CCr <60 mL/min; avoid concurrent use with ACE inhibitors.
- ↑levels and may ↑ risk oflithium toxicity.
- Colesevelam may ↓ levels; administer olmesartan
4 hr before colesevelam
