section name header

Indications ⬇

BEERS REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: bradycardia, chest pain, hypotension, palpitations, rebound hypertension, syncope

EENT: tinnitus

GI: constipation, dry mouth, abdominal pain, nausea

GU: erectile dysfunction

Neuro: drowsiness, headache, weakness, depression, dizziness, fatigue, insomnia, irritability

Resp: dyspnea

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Hypertension

ADHD

US Brand Names ⬆ ⬇

Intuniv, Tenex

Action ⬆ ⬇

  • Stimulates CNS alpha2-adrenergic receptors, producing a decrease in sympathetic outflow to heart, kidneys, and blood vessels. Result is decreased BP and peripheral resistance, a slight decrease in heart rate, and no change in cardiac output. Mechanism of action in ADHD is unknown.
Therapeutic effects:
  • Lowering of BP in hypertension.
  • Increased attention span in ADHD.

Classifications ⬆ ⬇

Therapeutic Classification: antihypertensives,

Pharmacologic Classification: alpha adrenergic agonists

Pharmacokinetics ⬆ ⬇

Absorption: Immediate-release is well absorbed (80%); extended-release has lower rate and extent of absorption (↑ absorption with high-fat meals).

Distribution: Appears to be widely distributed.

Metabolism/Excretion: 50% metabolized by the liver, 50% excreted unchanged by the kidneys.

Half-Life: 17 hr.

Canadian Brand Names ⬆ ⬇

Intuniv XR

Time/Action Profile ⬆ ⬇

(antihypertensive effect)

ROUTEONSETPEAKDURATION
PO (single dose)unknown8–12 hr24 hr
PO (multiple doses)within 1 wk1–3 mounknown

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

GWAHN-fa-seen

Code ⬆

NDC Code