Appendicitis/Peritonitis
- IV (Adults and Children
2 mo and >40 kg): 3.375 g every 6 hr. - IV (Children 9 mo and
40 kg and normal renal function): 112.5 mg (100 mg piperacillin/12.5 mg tazobactam)/kg every 8 hr. - IV (Infants 2–9 mo and 40 kg and normal renal function): 90 mg (80 mg piperacillin/10 mg tazobactam)/kg every 8 hr.
Renal Impairment
- IV (Adults): CCr 20–40 mL/min: 2.25 g every 6 hr; CCr <20 mL/min: 2.25 g every 8 hr; Hemodialysis: 2.25 g every 12 hr + 0.75 g following hemodialysis on hemodialysis days; Continuous ambulatory peritoneal dialysis: 2.25 g every 12 hr.
Nosocomial Pneumonia
- IV (Adults and Children 2 mo and >40 kg): 4.5 g every 6 hr.
- IV (Children 9 mo and 40 kg and normal renal function): 112.5 mg (100 mg piperacillin/12.5 mg tazobactam)/kg every 6 hr.
- IV (Infants 2–9 mo and 40 kg and normal renal function): 90 mg (80 mg piperacillin/10 mg tazobactam)/kg every 6 hr.
Renal Impairment
- IV (Adults): CCr 20–40 mL/min: 3.375 g every 6 hr; CCr <20 mL/min: 2.25 g every 6 hr; Hemodialysis: 2.25 g every 8 hr + 0.75 g following hemodialysis on hemodialysis days; Continuous ambulatory peritoneal dialysis: 2.25 g every 8 hr.
Skin and Skin Structure Infections, Gynecologic Infections, and Community-Acquired Pneumonia
- IV (Adults): 3.375 g every 6 hr.
Renal Impairment
- IV (Adults): CCr 20–40 mL/min: 2.25 g every 6 hr; CCr <20 mL/min: 2.25 g every 8 hr; Hemodialysis: 2.25 g every 12 hr + 0.75 g following hemodialysis on hemodialysis days; Continuous ambulatory peritoneal dialysis: 2.25 g every 12 hr.