Asthma

• Inhaln (Adults and Children 4 yr): 50 mcg (1 inhalation) twice daily (approximately 12 hr apart).

Prevention of Exercise-Induced Bronchospasm

• Inhaln (Adults and Children 4 yr): 50 mcg (1 inhalation) 30 min before exercise; additional doses should not be used for 12 hr.

COPD

• Inhaln (Adults): 50 mcg (1 inhalation) twice daily (approximately 12 hr apart).

Serevent Diskus

• Produces accumulation of cyclic adenosine monophosphate at beta₂-adrenergic receptors.
• Relatively specific for beta₂ (pulmonary) receptors.

• Bronchodilation.

Therapeutic Classification: bronchodilators

Pharmacologic Classification: adrenergics

Absorption: Minimal systemic absorption follows inhalation.

Distribution: Action is primarily local.

Metabolism/Excretion: Metabolized in the liver via the CYP3A4 isoenzyme; 60% excreted in feces, 25% excreted in urine.

Half-life: 3–4 hr.

(bronchodilation)

†9 hr in adolescents.

• Advise patient to take salmeterol as directed. Do not use more than the prescribed dose. If a regularly scheduled dose is missed, use as soon as possible and resume regular schedule. Do not double doses. If symptoms occur before next dose is due, use a rapid-acting inhaled bronchodilator.
• Instruct patient using powder for inhalation never to exhale into diskus device and always to hold device in a level horizontal position. Mouthpiece should be kept dry; never wash.
• Caution patient not to use salmeterol to treat acute symptoms. A rapid-acting inhaled beta-adrenergic bronchodilator should be used for relief of acute asthma attacks.
• Advise patients on chronic therapy not to use additional salmeterol to prevent exercise-induced bronchospasm. Patients using salmeterol for prevention of exercise-induced bronchospasm should not use additional doses of salmeterol for 12 hr after prophylactic administration.
• Advise patient to notify health care professional immediately if difficulty in breathing persists after use of salmeterol, if condition worsens, if more inhalations of rapid-acting bronchodilator than usual are needed to relieve an acute attack, or if using 4 or more inhalations of a rapid-acting bronchodilator for 2 or more consecutive days or more than 1 canister in an 8-wk period.
• Salmeterol should be used with inhaled corticosteroids and is not a substitute for corticosteroids or adrenergic bronchodilators. Advise patients using inhalation or systemic corticosteroids to consult health care professional before stopping or reducing therapy.
• Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
• Emphasize the importance of regular follow-up exams to determine progress during therapy.

sal-ME-te-role

NDC Code^*

• 0173- GlaxoSmithKline LLC
  • 0173-0520- SEREVENT DISKUS
    • 0173-0520-00- 1 INHALER in 1 CARTON (0173-0520-00) > 28 POWDER, METERED in 1 INHALER

• 0173- GlaxoSmithKline LLC
  • 0173-0521- SEREVENT DISKUS
    • 0173-0521-00- 1 INHALER in 1 CARTON (0173-0521-00) > 60 POWDER, METERED in 1 INHALER