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Indications ⬇

REMS


Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: changes in BP, edema, QT interval prolongation, tachycardia

Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), MELANOMA, photosensitivity, rash, SQUAMOUS CELL CARCINOMA, STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS

EENT: visual disturbances, eye hemorrhage

Endo: ADRENAL INSUFFICIENCY, hyperglycemia

F and E: hypokalemia, hypomagnesemia

GI: abdominal pain, diarrhea, HEPATOTOXICITY, nausea, pancreatitis, vomiting

MS: fluorosis, periostitis

Neuro: dizziness, hallucinations, headache

Misc: chills, fever, infusion reactions

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Invasive Aspergillosis, Scedosporiosis, or Fusariosis

Hepatic Impairment

Candidemia in Non-Neutropenic Patients or Other Deep Tissue Candida Infections

Hepatic Impairment

Esophageal Candidiasis

Hepatic Impairment

US Brand Names ⬆ ⬇

Vfend

Action ⬆ ⬇

  • Inhibits fungal ergosterol synthesis leading to production of abnormal fungal plasma membrane.
Therapeutic effects:
  • Antifungal activity.

Spectrum:

Classifications ⬆ ⬇

Therapeutic Classification: antifungals

Pharmacologic Classification: azoles

Pharmacokinetics ⬆ ⬇

Absorption: 96% absorbed following oral administration; IV administration results in complete bioavailability.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Primarily metabolized by liver via the CYP2C19, CYP2C9, and CYP3A4 isoenzymes; <2% excreted unchanged in urine. The CYP2C19 isoenzyme exhibits genetic polymorphism; 15–20% of Asian patients and 3–5% of White and Black patients may be poor metabolizers and may have significantly ↑ voriconazole concentrations and an ↑ risk of adverse effects.

Half-Life: Dose-dependent (adults: 6–9 hr); ↑ in hepatic impairment.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTEONSETPEAKDURATION
POrapid1–2 hr12 hr
IVrapidend of infusion12 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

vor-i-KON-a-zole

Code ⬆

NDC Code