do-LOX-e-teen
BEERS REMS
Contraindicated in:
Use Cautiously in:
May ↑ risk of suicide attempt/ideation, especially during early treatment or dose adjustment; this risk appears to be greater in adolescents or children
;CV: hypertension, orthostatic hypotension
Derm: ↑sweating, ERYTHEMA MULTIFORME, pruritus, rash, STEVENS-JOHNSON SYNDROME (SJS)
EENT: ↑intraocular pressure, blurred vision
Endo: SIADH
F and E: hyponatremia
GI: constipation, dry mouth, nausea, ↑liver enzymes, diarrhea, gastritis, HEPATOTOXICITY, PANCREATITIS, vomiting
GU: dysuria, ↓libido, delayed/absent orgasm, ejaculatory delay/failure, erectile dysfunction, urinary retention
Hemat: BLEEDING
Neuro: drowsiness, fatigue, insomnia, activation of mania, dizziness, fainting, falls, NEUROLEPTIC MALIGNANT SYNDROME, nightmares, SEIZURES, SUICIDAL THOUGHTS/BEHAVIORS, tremor
Misc: SEROTONIN SYNDROME
Drug-drug:
Drug-Natural Products:
Major Depressive Disorder
Generalized Anxiety Disorder
Diabetic Peripheral Neuropathic Pain
Fibromyalgia
Chronic Musculoskeletal Pain
Therapeutic Classification: antidepressants
Pharmacologic Classification: selective serotonin and norepinephrine reuptake inhibitors-SSNRIs
Absorption: Well absorbed following oral administration.
Distribution: Unknown.
Protein Binding: >90%.
Half-Life: 12 hr.
Advise patient, family, and caregivers to look for suicidality, especially during early therapy or dose changes. Notify health care provider immediately if thoughts about suicide or dying, attempts to commit suicide, new or worse depression or anxiety, agitation or restlessness, panic attacks, insomnia, new or worse irritability, aggressiveness, acting on dangerous impulses, mania, or other changes in mood or behavior occur.
NDC Code
