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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: rash

Neuro: confusion, difficulty sleeping, irritability, malaise

Misc: fever

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Therapeutic Dose (Folic acid deficiency)

Recommended Daily Allowance

Action ⬆ ⬇

  • Required for protein synthesis and red blood cell function. Stimulates the production of red blood cells, white blood cells, and platelets. Necessary for normal fetal development.
Therapeutic effects:
  • Restoration and maintenance of normal hematopoiesis.

Classifications ⬆ ⬇

Therapeutic Classification: antianemics, vitamins

Pharmacologic Classification: water soluble vitamins

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed from the GI tract and IM and SUBQ sites.

Distribution: Half of all stores are in the liver. Enters breast milk. Crosses the placenta.

Metabolism/Excretion: Converted by the liver to its active metabolite, dihydrofolate reductase. Excess amounts are excreted unchanged by the kidneys.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

(↑ in reticulocyte count)
ROUTEONSETPEAKDURATION
PO, IM, SUBQ, IV30–60 min1 hrunknown

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

FOE-lik A -sid

Code ⬆

NDC Code