HIV-1 Infection
- PO (Adults ): 150 mg twice daily or 300 mg once daily.
- PO (Children ≥3 mo): Oral solution: 5 mg/kg twice daily or 10 mg/kg once daily (max dose = 300 mg/day); Tablets: 14–19 kg: 75 mg twice daily or 150 mg once daily; 20–24 kg: 75 mg in AM, 150 mg in PM (or 225 mg once daily); ≥25 kg: 150 mg twice daily or 300 mg once daily.
Renal Impairment
- (Adults and Children ≥25 kg): CCr 30–49 mL/min: 150 mg once daily; CCr 15–29 mL/min: 150 mg initially; then 100 mg once daily; CCr 5–14 mL/min: 150 mg initially; then 50 mg once daily; CCr <5 mL/min: 50 mg initially; then 25 mg once daily.
Chronic Hepatitis B
- PO (Adults ): 100 mg once daily.
- PO (Children 2–17 yr): 3 mg/kg once daily (up to 100 mg/day).
Renal Impairment
- PO (Adults ): CCr 30–49 mL/min: 100 mg first dose; then 50 mg once daily; CCr 15–29 mL/min: 100 mg first dose; then 25 mg once daily; CCr 5–14 mL/min: 35 mg first dose; then 15 mg once daily; CCr <5 mL/min: 35 mg first dose; then 10 mg once daily.
