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Indications ⬇

BEERS REMS

Unlabeled Use:

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: hypotension, ARRHYTHMIAS, QT interval prolongation, TORSADES DE POINTES

Derm: photosensitivity

EENT: blurred vision, dry eyes, dry mouth

Endo: changes in blood glucose, gynecomastia

F and E: hyponatremia, SIADH

GI: constipation, hepatitis, paralytic ileus

GU: ↓libido, urinary retention

Hemat: blood dyscrasias

Metab: ↑appetite, weight gain

Neuro: lethargy, sedation, SUICIDAL THOUGHTS/BEHAVIORS

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Action ⬆ ⬇

  • Potentiates the effect of serotonin and norepinephrine in the CNS.
  • Has significant anticholinergic properties.
Therapeutic effects:
  • Antidepressant action.

Classifications ⬆ ⬇

Therapeutic Classification: antidepressants

Pharmacologic Classification: tricyclic antidepressants

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed from the GI tract.

Distribution: Widely distributed.

Protein Binding: 95%.

Metabolism/Excretion: Extensively metabolized by the liver, primarily by the CYP2D6 isoenzyme; the CYP2D6 enzyme system exhibits genetic polymorphism (∼7% of population may be poor metabolizers and may have significantly ↑ amitriptyline concentrations and an ↑ risk of adverse effects). Some metabolites have antidepressant activity. Undergoes enterohepatic recirculation and secretion into gastric juices.

Half-Life: 10–50 hr.

Canadian Brand Names ⬆ ⬇

Elavil

Time/Action Profile ⬆ ⬇

(antidepressant effect)

ROUTEONSETPEAKDURATION
PO2–3 wk (up to 30 days)2–6 wkdays–wk

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

a-mee-TRIP-ti-leen

Pill Image

amitriptylinehcl_195-1815.jpg

Code ⬆

NDC Code