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Indications ⬇

PO:

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: exfoliative dermatitis, hypersensitivity reactions (including erythema nodosum leprosum), photosensitivity, STEVENS-JOHNSON SYNDROME, systemic lupus erythematosus

EENT: blurred vision, tinnitus

GI: abdominal pain, HEPATOTOXICITY, nausea, PANCREATITIS, vomiting

Hemat: hemolytic anemia, AGRANULOCYTOSIS, METHEMOGLOBINEMIA, reticulocytosis

Neuro: headache, insomnia, mood changes, peripheral neuropathy, vertigo

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Leprosy

Dermatitis Herpetiformis

Pneumocystis jiroveciiPneumonia

Action ⬆ ⬇

  • Interferes with folate synthesis in susceptible organisms.
Therapeutic effects:
  • Bacteriostatic action.

Spectrum:

Classifications ⬆ ⬇

Therapeutic Classification: leprostatic agent, anti-infectives

Pharmacokinetics ⬆ ⬇

Absorption: Slowly absorbed (70–80%) following oral administration; acidic environment promotes absorption.

Distribution: Widely distributed to tissues.

Protein Binding: Dapsone: 70–90%; Monoacetyl dapsone (MADDS): 99%.

Metabolism/Excretion: Mostly metabolized by the liver to MADDS, its major metabolite, which is then metabolized back to dapsone.

Half-Life: 10–50 hr.

Time/Action Profile ⬆ ⬇

ROUTEONSETPEAKDURATION
POunknownunknownunknown

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

DAP-sohn

Code ⬆

NDC Code