section name header

Indications ⬇

BEERS REMS


Unlabeled Use:
  • Uncontrolled leg movements during sleep.
  • Neuralgias.
  • Infantile spasms.
  • Sedation.
  • Adjunct ­management of acute mania, acute psychosis, or insomnia.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: palpitations

Derm: rash

EENT: diplopia, nystagmus

GI: constipation, diarrhea, hepatitis

GU: dysuria, nocturia, urinary retention

Hemat: anemia, eosinophilia, leukopenia, thrombocytopenia

Metab: weight gain

Neuro: ataxia, behavioral changes, drowsiness, fatigue, hypotonia, sedation, slurred speech, SUICIDAL THOUGHTS

Resp: ↑secretions

Misc: fever, physical dependence, psychological dependence, tolerance

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

KlonoPIN

Action ⬆ ⬇

  • Anticonvulsant effects may be due to presynaptic inhibition.
  • Produces sedative effects in the CNS, probably by stimulating inhibitory GABA receptors.
Therapeutic effects:
  • Prevention of seizures.
  • Decreased manifestations of panic disorder.

Classifications ⬆ ⬇

Therapeutic Classification: anticonvulsants

Pharmacologic Classification: benzodiazepines

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed from the GI tract.

Distribution: Probably crosses the blood-brain barrier.

Metabolism/Excretion: Mostly metabolized by the liver.

Half-Life: 18–50 hr.

Contr. Subst. Schedule ⬆ ⬇

Schedule IV (C-IV)

Canadian Brand Names ⬆ ⬇

Rivotril

Time/Action Profile ⬆ ⬇

( anticonvulsant activity)

ROUTEONSETPEAKDURATION
PO20–60 min1–2 hr6–12 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

kloe-NA-ze-pam

Pill Image

clonazepam_195-8674.jpg
clonazepam_195-8720.jpg

Code ⬆

NDC Code