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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: HF

Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), itching, rash, STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS (TEN)

EENT: nasopharyngitis, smell disturbance

GI: anorexia, diarrhea, nausea, stomach pain, vomiting, drug-induced hepatitis, HEPATOTOXICITY, taste disturbance

Hemat: hemolytic uremic syndrome, neutropenia, pancytopenia, thrombotic thrombocytopenic purpura

Neuro: depression, headache

Resp: cough

Misc: fever

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Action ⬆ ⬇

  • Interferes with fungal cell wall synthesis (ergosterol biosynthesis) by inhibiting the enzyme squalene epoxidase.
Therapeutic effects:
  • Fungal cell death.

Spectrum:

Classifications ⬆ ⬇

Therapeutic Classification: antifungals

Pharmacokinetics ⬆ ⬇

Absorption: 70–80% absorbed after oral administration.

Distribution: Extensively distributed; penetrates dermis and epidermis; concentrates in stratum corneum, hair, scalp, and nails.

Protein Binding: 99%.

Metabolism/Excretion: Extensively metabolized by the liver by the CYP1A2, CYP2C9, CYP2C19, and CYP3A4 isoenzymes.

Half-Life: Plasma: 22 days; longer from skin and nails.

Canadian Brand Names ⬆ ⬇

LamISIL

Time/Action Profile ⬆ ⬇

(antifungal tissue concentrations)

ROUTEONSETPEAKDURATION
POseveral daysdays–wkseveral wk

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

ter-BI-na-feen

Code ⬆

NDC Code