Adult Dosing
Orthostatic hypotension
Hepatorenal Syndrome [Non-FDA approved]
Note:
- Dose should be taken during the daytime hours when the patient needs to be upright
- There should be at least 4-hr interval between doses; shortly before or upon arising in the morning, midday and late afternoon (not later than 6 pm)
- If required, doses may be given at 3-hr intervals to control symptoms, but not more frequently
- Should not be given after the evening meal or <4 hrs before bedtime
- Monitor supine and standing blood pressure regularly during therapy
Pediatric Dosing
- Safety and effectiveness in pediatric patients have not been established
[Outline]
See Supplemental Patient Information
- Marked elevation of supine arterial blood pressure can occur (BP >200 mmHg) with midodrine therapy; elevations, such as these, were seen in patients with elevated pre-treatment systolic blood pressures (mean 170 mmHg)
- There is no experience in treating patients with initial supine systolic pressure >180 mmHg; midodrine use in such patients is not recommended
- Monitor supine and sitting blood pressures in patients maintained on midodrine
- Promptly discontinue therapy if supine hypertension occurs or persists; carefully monitor blood pressure during co-administration with vasoconstrictive agents such as phenylephrine, ephedrine, dihydroergotamine, pseudoephedrine or phenylpropanolamine
- Bradycardia may occur during therapy due to vagal reflex. Patients who develop signs or symptoms signifying bradycardia should be advised to discontinue therapy and should be re-evaluated
- Monitor renal and hepatic functions prior to initiation of therapy and subsequently, as required
Cautions: Use cautiously in
- Renal impairment
- Hepatic impairment
- Hypertension
- Concomitant use with cardiac glycosides
- Use with psychopharmacologic agents
- Co-administration with beta-blockers
- Agents that reduce heart rate
- Urinary retention problems
- Diabetes mellitus
- History of visual problems
- Patients on fludrocortisone
Supplemental Patient Information
- Inform patients that certain over-the-counter products such as cold remedies and diet aids can elevate blood pressure and should be used carefully during therapy, as they may potentiate the pressor effects of midodrine
Pregnancy Category:C
Breastfeeding: Safety unknown; manufacturer advises caution.
Pricing data from www.DrugStore.com in U.S.A.
- Midodrine HCl 10 MG TABS [Bottle] (GLOBAL PHARMACEUTICAL CORP)
100 mg = $291.01
300 mg = $798.01 - ProAmatine 2.5 MG TABS [Bottle] (SHIRE US INC.)
100 mg = $139.99
300 mg = $399.97 - ProAmatine 5 MG TABS [Bottle] (SHIRE US INC.)
100 mg = $255.98
300 mg = $765.91
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
