Information ⬇
- History and physical examination: with special attention to oral, ocular, lymphatic examination and presence of other autoimmune disorders.
- Presence of autoantibodies is a hallmark of disease (ANA, RF, anti-Ro/SS-A, anti-La/SS-B).
- Other laboratory tests: ESR; CBC; renal, liver, and thyroid function tests; serum protein electrophoresis (SPEP) (hypergammaglobulinemia or monoclonal gammopathy common); UA.
- Ocular studies: to diagnose and quantitate KCS; Schirmer's test, Rose bengal staining.
- Oral examination: unstimulated salivary flow, dental examination.
- Labial salivary gland biopsy: demonstrates lymphocytic infiltration and destruction of glandular tissue.
Outline ⬆