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Basics

Description
Epidemiology

Incidence

  • Variable and dependent on definition and testing technique used (1)
  • Increasing yearly in the general population; the adjusted implantation incidence of permanent PPMs has increased 2.7-fold over 30 years (3)
  • Patients with high-grade AV block (AVB) have a higher incidence of PD than patients with sinus node disease (SND) (4). In older studies, the incidence of PD was 24–50% in AVB and 6–12% in SND. In more recent studies with different diagnostic criteria the incidence was much less (1).
  • In a recent study, the annual rate of new onset PD in PPM patients was 1.6% (4)
  • Following cardiac surgery 1–3% of patients need PPMs of which many develop PD (1)

Prevalence

  • In PPM patients, the reported prevalence of PD is highly variable with a historical published range from 5–30%
  • In one recent study, 2.1% of PPM patients were PD, and patients with AV block had a higher prevalence than patients with sick sinus syndrome or atrial fibrillation (AF) (5)

Morbidity

  • Impossible to quantify, however, PD might confer increased morbidity (6)
  • Risk of significant symptoms following an abrupt cessation of pacing, such as profound ventricular bradycardia, hypotension, syncope, inadequate perfusion, death.

Mortality

  • Impossible to quantify
  • Possible association between PD and cardiovascular as well as overall mortality (5,7)
  • Risk of cardiac arrest following an abrupt cessation of pacing
Etiology/Risk Factors
Physiology/Pathophysiology
Prevantative Measures

Diagnosis

Treatment

Temporary pacing modalities in the perioperative period may be used to stabilize a patient with urgent or emergent pacing indications: transesophageal, transcutaneous, and transvenous pacing. Esophageal pacing (EP) utilizes a specially constructed esophageal stethoscope with two stainless steel rings, designed to stimulate the left atrium. EP requires intact atrial and AV nodal function; thus it is absolutely contraindicated in the presence of AF or flutter, as well as significant AV nodal disease. Transcutaneous pacing utilizes 2 cutaneous pads with pacing achieved via an external defibrillator. Transvenous pacing is achieved by placing a temporary pacing wire through a central vein so that its tip lies in the right ventricle. It is more reliable and can therefore be used for a longer duration than EP or transcutaneous pacing.

Follow-Up

Closed Claims Data

Analyses of pacing systems show failures at multiple levels. The 1990–2002 FDA Data Analysis (11) showed that there were 2.25 million PPMs and 415,780 ICDs implanted in US. The annual malfunction replacement rate for PPMs was 4.6 per 1,000 implants and 20.7 per 1,000 implants for ICDs. 61 deaths were attributed to generator malfunction. Mechanical problems with device leads were common; the reported failure rate of ICD leads at 8 years was 28–40% (1).

References

  1. Korantzopoulos P , Letsas P , Grekas G , et al. Pacemaker dependency after implantation of electrophysiological devices. Europace. 2009;11:11511155.
  2. Bardy GH , Lee KL , Mark DB , et al. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med. 2005;352:225237.
  3. Uslan DZ , Tleyjeh IM , Baddour LM , et al. Temporal trends in permanent pacemaker implantation: A population-based study. Am Heart J. 2008;155: 896903.
  4. Nagatomo T , Abe H , Kikuchi K , et al. New onset of pacemaker dependency after permanent pacemaker implantation. Pacing Clin Electrophysiol. 2004;27:475479.
  5. Lelakowski J , Majewski J , Bednarek J , et al. Pacemaker dependency after pacemaker implantation. Cardiol J. 2007;14:8386.
  6. American Society of Anesthesiologists. Practice advisory for the perioperative management of patients with cardiac implantable electronic devices: Pacemakers and implantable cardioverter-defibrillators: An updated report by the American society of anesthesiologists task force on perioperative management of patients with cardiac implantable electronic devices. Anesthesiology. 2011;114:247261.
  7. Tang AS , Roberts RS , Kerr C , et al. Relationship between pacemaker dependency and the effect of pacing mode on cardiovascular outcomes. Circulation. 2001;103:30813085.
  8. Bernstein AD , Daubert JC , Fletcher RD , et al. The revised NASPE/BPEG generic code for antibradycardia, adaptive-rate, and multisite pacing. North American Society of Pacing and Electrophysiology/British Pacing and Electrophysiology Group. Pacing Clin Electrophysiol. 2002;25:260264.
  9. Lau W , Corcoran SJ , Mond HG. Pacemaker tachycardia in a minute ventilation rate-adaptive pacemaker induced by electrocardiographic monitoring. Pacing Clin Electrophysiol. 2006;29:438440.
  10. Crossley GH , Poole JE , Rozner MA , et al. The Heart Rhythm Society (HRS)/American Society of Anesthesiologists (ASA) Expert Consensus Statement on the Perioperative Management of Patients with Implantable Defibrillators, Pacemakers and Arrhythmia Monitors: Facilities and Patient Management This document was developed as a joint project with the American Society of Anesthesiologists (ASA), and in collaboration with the American Heart Association (AHA), and the Society of Thoracic Surgeons (STS). Heart Rhythm. 2011;8:11141154.
  11. Maisel WH , Moynahan M , Zuckerman BD , et al. Pacemaker and ICD generator malfunctions: analysis of Food and Drug Administration annual reports. JAMA. 2006;295:19011906.
  12. Maisel WH , Hauser RG , Hammill SC , et al. Recommendations from the Heart Rhythm Society Task force on Lead Performance Policies and Guidelines Developed in collaboration with the American College of Cardiology (ACC) and the American Heart Association (AHA). Heart Rhythm. 2009;6:869885.

Additional Reading

See Also (Topic, Algorithm, Electronic Media Element)

Codes

ICD9
ICD10

Clinical Pearls

Author(s)

Peter M. Schulman , MD

Marc Rozner , PhD, MD