Information
Editors
PaulaMaasilta
TuulaVasankari
Pulmonary Diseases Caused by Environmental Mycobacteria
Essentials
- Consider environmental (also "atypical" or "non-tuberculous") mycobacteria as causative agents in patients with
- persistent pulmonary infection and chronic pulmonary disease or immunosuppression
- undetermined prolonged pulmonary infections
- suspected pulmonary tuberculosis that responds poorly to treatment.
Epidemiology
- The incidence of infections caused by environmental mycobacteria is increasing.
- The infection is acquired from water or soil, etc.
- Human-to-human transmission has not been reported.
- Development of a disease often requires an earlier damage to the lungs (e.g. earlier tuberculosis, pulmonary fibrosis, etc.)
Causative agent
- The following species cause pulmonary infections: M. avium-intracellulare, M. kansasi, M. xenopi, M. malmoense, M. scrofulaceum, M. simiae, M. szulgai, M. chelonei and M. fortuitum.
Symptoms
- Cough
- Sputum production
- Dyspnoea
- Weight loss
- Fever and bloody sputum are rare.
Investigations
Bacterial culture
- Repeated ample growth of the same species of environmental Mycobacteria in the culture of sputum or bronchial secretion is a significant finding.
- Pulmonary disease caused by environmental mycobacteria must be differentiated from mere colonization (or contamination of the specimen).
Radiology
- In subacute disease the parenchymal infiltrates and caverns are situated unilaterally in the upper lobe.
- In chronic forms the patient often has bilateral fibrotic changes.
Treatment
- The treatment is clearly more difficult than the treatment of ordinary tuberculosis.
- Treatment options include antituberculous medication, other antimicrobial drugs, and occasionally surgery.
- Eradication of the environmental mycobacteria is not always possible.
- Treatment is indicated if
- there is growth in sputum culture samples repeatedly or in a single sample taken from a location that otherwise is sterile and
- chest x-ray shows findings that match with an infection caused by environmental mycobacteria and
- the patient has matching symptoms.
- If the patient has no or only minimal symptoms, follow-up without medication is in some cases a valid option.
- Treatment is started in specialized care.
Notification
- Follow the local regulation concerning notification of infectious diseases and reimbursement of treatment.
References
- Haworth CS, Banks J, Capstick T ym. British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD). Thorax 2017;72(Suppl 2):ii1-ii64. [PubMed]