• Major depressive episode without melancholia (usually reserved for patients who do not tolerate or respond to other modes of therapy [e.g. tricyclic antidepressants, SSRIs, SSNRIs or electroconvulsive therapy]).

Contraindicated in:

• Hypersensitivity
• Liver disease
• Cerebrovascular disease
• Cardiovascular disease
• Hypertension
• Pheochromocytoma
• Patients undergoing elective surgery requiring general anesthesia (should be discontinued at least 10 days before surgery)
• History of headache
• Excessive consumption of caffeine
• Concurrent use of meperidine, SSRI antidepressants, SNRI antidepressants, tricyclic antidepressants, tetracyclic antidepressants, nefazodone, trazodone, procarbazine, vilazodone, vortioxetine, rasagiline, selegiline, linezolid, carbamazepine, cyclobenzaprine, bupropion, buspirone, sympathomimetics, other MAO inhibitors, dextromethorphan, dopamine, levodopa, meperidine, tapentadol, milnacipran, triptans, alcohol, general anesthetics, diuretics, antihistamines, or tryptophan
• Concurrent use of foods containing high concentrations of tyramine (see Appendix M)
• Lactation: Lactation.

Use Cautiously in:

• Patients who may be suicidal or have a history of drug dependency
• Hyperthyroidism
• Schizophrenia
• Bipolar disorder
• Seizure disorders
• Renal dysfunction
• Diabetes (↑ risk of hypoglycemia)
• OB: Use during pregnancy only if potential maternal benefit justifies potential fetal risk
• Pedi: Safety and effectiveness not established; may ↑ risk of suicide attempt/ideation especially during first 1–2 mo of treatment or with dose adjustments
• Geri: ↑ risk of adverse reactions in older adults.

CV: edema, HYPERTENSIVE CRISIS, orthostatic hypotension, tachycardia.

Derm: alopecia, rash.

EENT: blurred vision, tinnitus.

Endo: hypoglycemia.

GI: abdominal pain, anorexia, constipation, diarrhea, dry mouth, HEPATOTOXICITY, nausea.

GU: sexual dysfunction, urinary retention.

Hemat: AGRANULOCYTOSIS, leukopenia, thrombocytopenia.

MS: muscle spasm.

Neuro: confusion, dizziness, drowsiness, headache, insomnia, paresthesia, restlessness, SEIZURES, tremor, weakness.

Drug-Drug:

• Serious, potentially fatal adverse reactions may occur with concurrent use of other antidepressants (SSRIs, SSNRIs, bupropion, tricyclics, tetracyclics, nefazodone, trazodone, vilazodone, vortioxetine), carbamazepine, cyclobenzaprine, milnacipran, procarbazine, rasagiline, selegiline, or tapentadol. Avoid using within 2 wk of each other (wait 5 wk from end of fluoxetine therapy).
• Hypertensive crisis may occur with amphetamines, levodopa, dopamine, epinephrine, norepinephrine, methylphenidate, triptans, or vasoconstrictors.
• Hypertension or hypotension, coma, seizures, respiratory depression, and death may occur with meperidine (avoid using within 2–3 wk of MAO inhibitor therapy).
• Concurrent use with dextromethorphanmay produce psychosis or bizarre behavior.
• Hypertension may occur with concurrent use of buspirone; avoid using within 2 wk of each other.
• Additive hypotension may occur with antihypertensives, spinal anesthesia, opioids, or barbiturates.
• Additive hypoglycemia may occur with insulins or oral hypoglycemic agents.
• Risk of seizures may be ↑ with tramadol.

Drug-Natural Products:

• Serious, potentially fatal adverse effects (serotonin syndrome) may occur with concomitant use of St. John's wort and SAMe.
• Hypertensive crises may occur with large amounts of caffeine-containing herbs (cola nut, guarana, or malt).
• Insomnia, headache, tremor, hypomania may occur with ginseng.
• Hypertensive crises, disorientation, and memory impairment may occur with tryptophan or supplements containing tyrosine or phenylalanine.

Drug-Food:

• Hypertensive crisis may occur with ingestion of foods containing high concentrations of tyramine (see Appendix M).
• Consumption of foods or beverages with high caffeine content ↑ the risk of hypertension and arrhythmias.

(Generic available)

• Tablets: 10 mg;

• PO (Adults): 30 mg/day in 2 divided doses (morning and afternoon); after 2 wk can ↑ by 10 mg/day, at 1–3 wk intervals, up to 60 mg/day in 2 divided doses.

Parnate

• Inhibits the enzyme monoamine oxidase, resulting in an accumulation of various neurotransmitters (dopamine, epinephrine, norepinephrine, and serotonin) in the body.

• Improved mood in depressed patients.

Therapeutic Classification: antidepressants

Pharmacologic Classification: monamine oxidase inhibitors

Absorption: Unknown.

Distribution: Crosses the placenta and enters breast milk.

Metabolism/Excretion: Unknown.

Half-life: 90–190 min.

(antidepressant effect)

• Instruct patient to take medication as directed. Take missed doses if remembered within 2 hr; otherwise, omit and return to regular dose schedule. Do not discontinue abruptly as withdrawal symptoms (nausea, vomiting, malaise, nightmares, agitation, psychosis, seizures) may occur. Advise patient to read Medication Guide before starting therapy and with each Rx refill in case of changes.
• Caution patient to avoid alcohol, CNS depressants, OTC drugs, and foods or beverages containing tyramine (see Appendix M) or excessive caffeine during and for at least 2 wk after therapy has been discontinued; they may precipitate a hypertensive crisis. Instruct patient to notify health care professional immediately if symptoms of hypertensive crisis (e.g. severe headache, palpitations, chest or throat tightness, sweating, dizziness, neck stiffness, nausea, or vomiting) develop.
• Instruct parents or guardians of children to contact health care professional immediately if child exhibits any suicidal thoughts or behaviors (e.g. worsening depression, new or worsening anxiety, agitation, panic attacks, insomnia, new or worsening irritability, violent behavior, impulsive actions, excessive talking, unusual changes in mood or behavior) or if signs and symptoms of serotonin syndrome (agitation, confusion, seeing or hearing things that are not real (hallucinations), coma, rapid pulse, changes in blood pressure, dizziness, sweating, flushing, high body temperature (hyperthermia), fever, seizures, tremors, stiff muscles, or muscle twitching, becoming unstable, nausea, vomiting, diarrhea) occur.
• May cause dizziness or drowsiness. Caution patient to avoid driving and other activities requiring alertness until response to medication is known.
• Caution patient to change positions slowly to minimize orthostatic hypotension. Geriatric patients are at increased risk for this side effect.
• Instruct patient to consult with health care professional before taking any new prescription, OTC, or herbal product.
• Advise patient to notify health care professional if dry mouth, urinary retention, or constipation occurs. Frequent rinses, good oral hygiene, and sugarless candy or gum may diminish dry mouth. An increase in fluid intake, fiber, and exercise may prevent constipation.
• Advise patient to notify health care professional of medication regimen before surgery. If possible, therapy should be discontinued at least 2 wk before surgery.
• May be teratogenic. Advise females of reproductive potential to use effective contraception and to avoid breastfeeding during therapy. Advise patient to notify healthcare professional immediately if pregnancy is suspected.
• Instruct patient to carry identification describing medication regimen at all times.
• Emphasize the importance of participation in psychotherapy if recommended by health care professional and follow-up exams to evaluate progress.

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