Contraindicated in:
Use Cautiously in:
CV: orthostatic hypotension.
Derm: flushing, sweating.
EENT: blurred vision, diplopia, miosis.
Endo: adrenal insufficiency.
GI: constipation, GI obstruction, choking, dry mouth, nausea, vomiting.
GU: urinary retention.
Neuro: confusion, sedation, dizziness, dysphoria, euphoria, floating feeling, hallucinations, headache, unusual dreams.
Resp: RESPIRATORY DEPRESSION (INCLUDING CENTRAL SLEEP APNEA AND SLEEP-RELATED HYPOXEMIA).
Misc: physical dependence, psychological dependence, tolerance.
Drug-Drug:
(Generic available)
Hepatic Impairment
Therapeutic Classification: opioid analgesics
Pharmacologic Classification: opioid agonists, opioid agonists nonopioid analgesic combinations
Absorption: Well absorbed from the GI tract.
Distribution: Widely distributed. Crosses the placenta; enters breast milk.
Protein Binding: 3845%.
Metabolism/Excretion: Mostly metabolized by the liver by the CYP3A4 isoenzyme, and to a lesser extent by the CYP2D6 isoenzyme.
Half-life: 23 hr.
(analgesic effects)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO | 1015 min | 6090 min | 36 hr |
PO-ER | 1015 min | 3 hr | 12 hr |
Extended-release.