Contraindicated in:
Use Cautiously in:
Derm: pruritus, rash, sweating, urticaria.
EENT: acute iritis, pharyngitis, rhinitis, sinusitis.
Endo: fat redistribution, hyperglycemia, hyperuricemia.
F and E: dehydration.
GI: diarrhea, anorexia, dyspepsia, ↑ liver enzymes, epigastric pain, flatulence, GI bleeding, hepatitis, nausea, oral ulcerations, pancreatitis, vomiting.
GU: nephrolithiasis, sexual dysfunction.
Hemat: anemia, leukopenia, thrombocytopenia.
Metab: hyperlipidemia.
MS: arthralgia, arthritis, back pain, myalgia, myopathy.
Neuro: SEIZURES, anxiety, depression, dizziness, drowsiness, emotional lability, headache, hyperkinesia, insomnia, malaise, migraine headache, myasthenia, paresthesia, sleep disorders, suicidal ideation, weakness.
Resp: dyspnea.
Misc: allergic reactions, fever, immune reconstitution syndrome.
Drug-Drug:
Drug-Natural Products:
Drug-Food:
Absorption: Well absorbed after oral administration.
Distribution: Unknown.
Protein Binding: >98%.
Metabolism/Excretion: Mostly metabolized (CYP3A4 enzyme system) (CYP2C19 and CYP3A4); the CYP2C19 enzyme system exhibits genetic polymorphism; 1520% of Asian patients and 35% of Caucasian and Black patients may be poor metabolizers and may have significantly ↑ nelfinavir concentrations and an ↑ risk of adverse effects. Excreted in feces as metabolites (78%) or unchanged drug (22%); minimal renal excretion.
Half-life: 3.55 hr.