Contraindicated in:
Use Cautiously in:
CV: TORSADE DE POINTES, heart block, PR interval prolongation, QT interval prolongation, thrombophlebitis.
Derm: STEVENS-JOHNSON SYNDROME, photosensitivity, severe cutaneous reactions.
Endo: fat redistribution, hyperglycemia.
GI: abdominal discomfort, diarrhea, ↑liver enzymes, jaundice, nausea.
Hemat: acute myeloblastic leukemia, hemolytic anemia, thrombocytopenia.
Neuro: ataxia , SEIZURES, confusion, headache, mental depression, psychic disorders, weakness.
Misc: immune reconstitution syndrome.
Drug-Drug:
Drug-Natural Products:
Drug-Food:
Absorption: Incompletely absorbed after oral administration; rapidly undergoes extensive first-pass hepatic metabolism.
Distribution: Distributes into tissues, but CNS penetration is poor.
Protein Binding: 98%.
Metabolism/Excretion: Mostly metabolized by the liver. <1% excreted unchanged in urine.
Half-life: 13 hr.