Contraindicated in:
Use Cautiously in:
When used in combination with other antiretrovirals
CV: ↑PR interval, heart block.
Derm: DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), ERYTHEMA MULTIFORME, STEVENS-JOHNSON SYNDROME, rash.
Endo: Graves' disease, hyperglycemia.
GI: HEPATOTOXICITY, nausea, abdominal pain, autoimmune hepatitis, cholelithiasis, diarrhea, hyperbilirubinemia, jaundice, ↑ liver enzymes, vomiting.
GU: interstitial nephritis, nephrolithiasis.
Metab: fat redistribution.
MS: myalgia, polymyositis.
Neuro: Guillain-Barré syndrome , headache, depression, dizziness, insomnia.
Misc: ANGIOEDEMA, fever, immune reconstitution syndrome.
Drug-Drug:
Drug-Natural Products:
(Generic available)
Renal Impairment
Hepatic Impairment
Absorption: Rapidly absorbed (↑ by food).
Distribution: Enters cerebrospinal fluid and semen.
Metabolism/Excretion: 80% metabolized (CYP3A); 13% excreted unchanged in urine.
Half-life: 7 hr.