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Indications

BEERS REMS

Unlabeled Uses:

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: peripheral edema, bradycardia, chest pain, HF, hypotension, palpitations, syncope, tachycardia.

Derm: flushing, sweating, dermatitis, erythema multiforme, photosensitivity, pruritus/urticaria, rash, STEVENS-JOHNSON SYNDROME.

EENT: blurred vision, disturbed equilibrium, epistaxis, tinnitus.

Endo: gynecomastia, hyperglycemia.

GI: liver enzymes, GI obstruction, anorexia, constipation, diarrhea, dry mouth, dyspepsia, nausea, vomiting.

GU: dysuria, nocturia, polyuria, sexual dysfunction, urinary frequency.

Hemat: anemia, leukopenia, thrombocytopenia.

Metab: weight gain.

MS: joint stiffness, muscle cramps.

Neuro: paresthesia, tremor.

Resp: cough, dyspnea, shortness of breath.
Misc: gingival hyperplasia.

Interactions

Drug-Drug:

Drug-Natural Products:

Drug-Food:

Availability

(Generic available)

Route/Dosage

US Brand Names

Adalat CC, Afeditab CR, Procardia, Procardia XL

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antianginals, antihypertensives

Pharmacologic Classification: calcium channel blockers

Pharmacokinetics

Absorption: Well absorbed after oral administration, but large amounts are rapidly metabolized, resulting in bioavailability (45–70%); bioavailability is (80%) with extended-release forms.

Distribution: Unknown.

Protein Binding: 92–98%.

Metabolism/Excretion: Mostly metabolized by the liver by the CYP3A4 isoenzyme.

Half-life: 2–5 hr.

Canadian Brand Names

Adalat XL

Time/Action Profile

ROUTEONSETPEAKDURATION
PO20 minunknown6–8 hr
PO–ERunknown6 hr24 hr

Patient/Family Teaching

Pronunciation

nye-FED-i-peen