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Indications

BEERS REMS

OTC:

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS, cutaneous lupus erythematosus, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), rash, STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS (TEN).

F and E: hypocalcemia (especially if treatment duration ge.gif3 mo), hypokalemia (especially if treatment duration ge.gif3 mo), hypomagnesemia (especially if treatment duration ge.gif3 mo).

GI: diarrhea, abdominal pain, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), fundic gland polyps, nausea.

GU: acute tubulointerstitial nephritis.

Hemat: vitamin B12 deficiency.

MS: bone fracture.

Neuro: dizziness, headache.
Misc: (INCLUDING ANAPHYLAXIS, ANGIOEDEMA, OR ACUTE TUBULOINTERSTITIAL NEPHRITIS)HYPERSENSITIVITY REACTIONS , systemic lupus erythematosus.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

US Brand Names

Prevacid, Prevacid 24 Hr, Prevacid SoluTab

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antiulcer agents

Pharmacologic Classification: proton pump inhibitors

Pharmacokinetics

Absorption: 80% absorbed after oral administration.

Distribution: Unknown.

Protein Binding: 97%.

Metabolism/Excretion: Extensively metabolized by the liver to inactive compounds. Converted intracellularly to at least two other antisecretory compounds.

Half-life: Children: 1.2–1.5 hr; Adults: 1.3–1.7 hr ( in geriatric patients and patients with impaired hepatic function).

Time/Action Profile

(acid suppression)

ROUTEONSETPEAKDURATION
POrapid1.7 hrmore than 24 hr

Patient/Family Teaching

Pronunciation

lan-SOE-pra-zole