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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: rash.

Endo: hyperglycemia.

GI: abdominal pain, constipation, drug-induced hepatitis, liver enzymes, nausea.

Hemat: thrombocytopenia.

MS: immune-mediated necrotizing myopathy, myalgia, RHABDOMYOLYSIS.

Neuro: amnesia, confusion, memory loss, weakness.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

Renal Impairment

US Brand Names

Crestor

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: lipid-lowering agents

Pharmacologic Classification: hmg coa reductase inhibitors (statins)

Pharmacokinetics

Absorption: 20% absorbed following oral administration.

Distribution: Unknown.

Metabolism/Excretion: 10% metabolized, 90% excreted unchanged in feces.

Half-life: 19 hr.

Time/Action Profile

(effect on lipids)

ROUTEONSETPEAKDURATION
POunknown2–4 wkunknown

Patient/Family Teaching

Pronunciation

roe-SOO-va-sta-tin

Pill Image

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