SIM-va-sta-tin 
Absorption: 85% absorbed, but rapidly metabolized.
Distribution: Unknown.
Protein Binding: 95%.
Metabolism/Excretion: Extensively metabolized by the liver, most during first pass; excreted in bile and feces; 13% excreted unchanged by the kidneys.
Half-life: Unknown.
Contraindicated in:
Use Cautiously in:
1 g/day of niacin (↑ risk of myopathy; do not use simvastatin 80 mg/day in these patients)CNS: amnesia, confusion, dizziness, headache, insomnia, memory loss, weakness.
GI: abdominal cramps, constipation, diarrhea, flatus, heartburn, altered taste, drug-induced hepatitis, dyspepsia, ↑ liver enzymes, nausea, pancreatitis.
GU: erectile dysfunction.
Derm: rashes, pruritus.
Endo: hyperglycemia.
MS: RHABDOMYOLYSIS, arthralgia, immune-mediated necrotizing myopathy, myopathy (↑ risk with 80 mg dose).
Misc: hypersensitivity reactions.
Drug-Drug:
Drug-Food:
The 80 mg dose should be restricted to patients who have been taking this dose for 12 mo without evidence of muscle toxicity
12 mo] without evidence of myopathy).Renal Impairment
Therapeutic Classification: lipid-lowering agents
Pharmacologic Classification: hmg coa reductase inhibitors (statin)
(Generic available)
NDC Code*
