Absorption: Highly variable.
Distribution: Unknown.
Metabolism/Excretion: Metabolized in the gut (P-glycoprotein) and by the liver (primarily CYP3A and less by CYP2D6); <5% excreted unchanged in urine and feces.
Half-life: 7 hr.
Contraindicated in:
Use Cautiously in:
CV: TORSADES DE POINTES, palpitations, QTc prolongation.
EENT: tinnitus.
GI: abdominal pain, constipation, dry mouth, nausea, vomiting.
GU: acute renal failure.
Neuro: dizziness, headache.
Drug-Drug:
Drug-Natural Products:
Drug-Food:
NDC Code*