DAP-sohn 
Unlabeled Use:
Spectrum:
Absorption: Slowly absorbed (70–80%) following oral administration; acidic environment promotes absorption.
Distribution: Widely distributed; crosses the placenta and enters breast milk in significant concentrations.
Protein Binding: Dapsone — 70–90%; MADDS — 99%.
Metabolism/Excretion: Mostly metabolized by the liver to monoacetyl dapsone (MADDS), its major metabolite, which is then metabolized back to dapsone.
Half-life: 10–50 hr.
Contraindicated in:
Use Cautiously in:
Derm: STEVENS-JOHNSON SYNDROME, exfoliative dermatitis, hypersensitivity reactions (including erythema nodosum leprosum), photosensitivity, systemic lupus erythematosus.
EENT: blurred vision, tinnitus, pharyngitis (topical).
GI: HEPATOTOXICITY, PANCREATITIS, abdominal pain, nausea, vomiting.
Hemat: AGRANULOCYTOSIS, METHEMOGLOBINEMIA, hemolytic anemia, reticulocytosis.
Neuro: peripheral neuropathy, headache, insomnia, mood changes, tonic-clonic movements (topical), vertigo.
Drug-Drug:
Drug-Natural Products:
Leprosy
Dermatitis Herpetiformis
Acne Vulgaris
12 yrs): 5% gel — Apply small amount twice daily.9 yr): 7.5% gel — Apply small amount once daily.Pneumocystis jiroveciiPneumonia
NDC Code*