Therapeutic Classification: antirheumatics, nonopioid analgesics
Pharmacologic Classification: nonsteroidal anti inflammatory drugs nsaids
BEERS REMS
Topical (3% gel)
Absorption: Undergoes first-pass metabolism by liver which results in 50% bioavailability. Oral diclofenac sodium is a delayed-release dose form. Diclofenac potassium is an immediate-release dose form. 610% of topical gel is systemically absorbed.
Distribution: Crosses the placenta.
Protein Binding: >99%.
Half-Life: 2 hr.
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO (inflammation) | few days1 wk | ≥2 wk | unknown |
PO (pain) | 30 min | unknown | up to 8 hr |
Top (gel and patch) | unknown | 1020 hr | unknown |
Top (solution) | unknown | unknown | unknown |
Contraindicated in:
Use Cautiously in:
CV: edema, HF, hypertension, MI
Derm: pruritus, rash, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), eczema, EXFOLIATIVE DERMATITIS, photosensitivity, STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS (TEN)
EENT: tinnitus
F and E: hyperkalemia
GI: abdominal pain, constipation, diarrhea, dyspepsia, flatulence, GI BLEEDING, heartburn, HEPATOTOXICITY, nausea, vomiting
GU: acute renal failure, hematuria
Hemat: anemia, prolonged bleeding time
Local:
Topical only
contact dermatitis, dry skin, exfoliationPrimarily noted for oral administration
Drug-drug:
Drug-Natural Products:
Diclofenac
Hepatic Impairment
Diclofenac Potassium
Diclofenac Sodium
Diclofenac Epolamine
Lab Test Considerations:
diclofenac (oral): Zorvolex,
diclofenac potassium (oral): Cambia, Cataflam, Lofena, Zipsor,
diclofenac sodium (oral): Voltaren XR,
diclofenac sodium (rectal suppository):
diclofenac sodium (topical gel): Solaraze, Voltaren,
diclofenac sodium (topical solution): Pennsaid,
diclofenac epolamine (topical patch): Flector, Licart
NDC Code