Therapeutic Classification: corticosteroids (intermediate-acting), immune modifiers
Pharmacologic Classification: corticosteroids
REMS
Absorption: Well absorbed following oral administration.
Distribution: Widely distributed.
Half-Life: 2.13.5 hr (plasma), 1836 hr (tissue); adrenal suppression lasts 1.251.5 days.
Contraindicated in:
Use Cautiously in:
Adverse reactions/side effects are much more common with high-dose/long-term therapy
CV: hypertension
Derm: acne, ↓wound healing, ecchymoses, hirsutism, petechiae
EENT: cataracts, ↑intraocular pressure
Endo: adrenal suppression, cushingoid appearance (moon face, buffalo hump), hyperglycemia
F and E: fluid retention (long-term high doses), hypokalemia, hypokalemic alkalosis
GI: anorexia, nausea, PEPTIC ULCERATION, vomiting
Hemat: THROMBOEMBOLISM, thrombophlebitis
MS: muscle wasting, osteoporosis, avascular necrosis of joints, muscle pain
Neuro: depression, euphoria, headache, ↑intracranial pressure (children only), personality changes, psychoses, restlessness
Misc: INFECTION, KAPOSI'S SARCOMA
Drug-drug:
Lab Test Considerations:
NDC Code