di-JOX-in
Therapeutic Classification: antiarrhythmics, inotropics
Pharmacologic Classification: digitalis glycosides
BEERS REMS, High Alert
Absorption: 60–80% absorbed after oral administration of tablets; 70–85% absorbed after administration of elixir; 80% absorbed from IM sites (IM route not recommended due to pain/irritation). IV administration results in complete bioavailability.
Distribution: Widely distributed to tissues.
Half-Life: 36–48 hr (↑ in renal impairment).
(antiarrhythmic or inotropic effects, provided that a loading dose has been given)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO | 30–120 min | 2–8 hr | 2–4 days‡ |
| IM | 30 min | 4–6 hr | 2–4 days‡ |
| IV | 5–30 min | 1–4 hr | 2–4 days‡ |
‡Duration listed is that for normal renal function; in impaired renal function, duration will be longer.
Contraindicated in:
Use Cautiously in:
CV: bradycardia, ARRHYTHMIAS, ECG changes, heart block
EENT: blurred vision, yellow or green vision
GI: anorexia, nausea, vomiting, diarrhea
Hemat: thrombocytopenia
Drug-drug:
Drug-Natural Products:
Lab Test Considerations:
Toxicity and Overdose:
Digoxin has a narrow therapeutic range. Medication errors associated with digoxin include miscalculation of pediatric doses and insufficient monitoring of digoxin levels.
IV Administration:
NDC Code
