quinine

ROUTE	ONSET	PEAK	DURATION
PO	unknown	3.2–5.9 hr	8 hr

Contraindicated in:

Hypersensitivity to quinine, quinidine, or mefloquine;
History of previous serious adverse reaction to quinine including thrombotic thrombocytopenic purpura, thrombocytopenia, acute intravascular hemolysis, hemoglobinuria, or hemoglobinemia;
QTc prolongation or conditions predisposing to QTc prolongation including hypokalemia and bradycardia;
Concurrent use of Class IA or Class III antiarrhythmics, mefloquine, pimozide, or macrolide anti-infectives (↑ risk of arrhythmias);
Myasthenia gravis;
Optic neuritis;
Severe hepatic impairment.

Use Cautiously in:

Glucose–6–phosphate deficiency (↑ risk hemolysis);
Recurrent or interrupted malaria therapy;
History of arrhythmias, especially QTc prolongation;
Atrial fibrillation/flutter (may cause paradoxical ↑ in ventricular response);
Hypoglycemia;
History of thrombocytopenic purpura;
Mild or moderate hepatic impairment;
OB: Use only if potential maternal benefit justifies potential fetal risk; may risk of hypoglycemia in mother especially during 3rd trimester;
Lactation: Use while breastfeeding only if potential maternal benefit justifies potential risk to infant;
Pedi: Children 16 yr (safety and effectiveness not established).

Adv. Reactions/Side Effects ⬆ ⬇

CV: PR interval prolongation, QT interval prolongation, TORSADES DE POINTES

Derm: rash, STEVENS-JOHNSON SYNDROME

Endo: hypoglycemia

GI: abdominal cramps/pain, diarrhea, nausea, vomiting, hepatotoxicity

GU: ↓fertility (males)

Hemat: bleeding, blood dyscrasias, hemolytic anemia, HEMOLYTIC UREMIC SYNDROME, THROMBOCYTOPENIA, THROMBOTIC THROMBOCYTOPENIC PUPURA

Misc: cinchonism, HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND FEVER)

Interactions ⬆ ⬇

Drug-drug:

Concurrent use of Class IA antiarrhythmics (quinidine, procainamide, disopyramide, Class III antiarrhythmics, mefloquine, pimozide, or macrolide anti-infectives ↑ risk of arrhythmias and should be avoided.
Antacids containing aluminum or magnesium↓ absorption; avoid concurrent use.
Cimetidine, ketoconazole, ritonavir, tetracycline, theophylline, and erythromycin may ↑ levels; avoid concurrent use with erythromycin or ritonavir.
Rifampin and rifabutin may ↓ levels; avoid concurrent use with rifampin.
May ↑ effects of neuromuscular blocking agents.
May ↑ risk of hemolytic, ototoxic, or neurotoxic reactions when used concurrently with agents sharing these toxicities.
Concurrent use with mefloquine↑ risk of seizures and adverse cardiovascular reactions.
Urinary alkalinizers including acetazolamide and sodium bicarbonate may ↑ blood levels.
May ↑ levels of carbamazepine, phenobarbital, atorvastatin, simvastatin, lovastatin, desipramine, dextromethorphan, digoxin, and warfarin.
Carbamazepine, phenobarbital, and phenytoin may ↓ levels.

Route/Dosage ⬆ ⬇

PO (Adults ): 648 mg every 8 hr for 7 days.

Renal Impairment

PO (Adults ): Severe chronic renal failure: 648 mg initially, then 324 mg every 12 hr for 7 days.

Availability ⬆ ⬇

(Generic available)

Capsules: 200 mg; 300 mg; 324 mg

Assessment ⬆ ⬇

Malaria: Assess patient for improvement in signs and symptoms of condition daily during therapy.
Assess for rash periodically during therapy. May cause Stevens-Johnson syndrome or toxic epidermal necrolysis. Discontinue therapy if severe or if accompanied with fever, general malaise, fatigue, muscle or joint aches, blisters, oral lesions, conjunctivitis, hepatitis and/or eosinophilia.

Lab Test Considerations:

Monitor for thrombocytopenia; usually resolved within a wk of discontinuation, but may cause a fatal hemorrhage if quinine is not discontinued.
- May cause ↑ urinary 17-ketogenic steroids when metyrapone or Zimmerman method is used.

Toxicity and Overdose:

Plasma quinine levels of >10 mcg/mL may cause tinnitus and impaired hearing.
- Signs of toxicity or cinchonism include tinnitus, headache, nausea, and slightly disturbed vision; usually disappear rapidly upon discontinuing quinine.

Implementation ⬆ ⬇

Do not confuse quinine with quinidine.
PO: Administer with or after meals to minimize GI distress. Aluminum-containing antacids will decrease and delay absorption; avoid concurrent use.

Patient/Family Teaching ⬆ ⬇

Instruct patient to take medication as directed and continue full course of therapy, even if feeling better. Take missed doses as soon as remembered, unless almost time for the next dose. If more than 4 hr has elapsed since missed dose, wait and take the next dose as scheduled. Do not double doses or take more than recommended. Advise patient to read the Patient Information leaflet prior to starting therapy and with each Rx refill.
Review methods of minimizing exposure to mosquitoes with patients receiving quinine (use insect repellent, wear long-sleeved shirt and long trousers, use screen or netting).
Quinine may cause visual changes. Caution patient to avoid driving or other activities requiring alertness until response to medication is known.
May cause diarrhea, nausea, stomach cramps or pain, vomiting, or ringing in the ears. Advise patient to notify health care professional promptly if these become pronounced.
Advise patient to stop quinine and notify health care professional of any evidence of allergy (flushing, itching, rash, fever, facial swelling, stomach pain, difficult breathing, ringing in the ears, visual problems) or rash.
Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and consult health care professional before taking any new medications.
Advise patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Evaluation/Desired Outcomes ⬆ ⬇

Improvement in signs and symptoms of malaria. Advise patient to contact health care professional if not feeling better within 1–2 days or if fever returns following therapy.

US Brand Names ⬆ ⬇

Code ⬆

NDC Code

0093- Teva Pharmaceuticals USA, Inc.
- 0093-3002- Quinine Sulfate
  - 0093-3002-56- 30 CAPSULE in 1 BOTTLE (0093-3002-56)

0220- Boiron
- 0220-1306- Chininum sulphuricum
  - 0220-1306-41- 9 [hp_C] in 1 TUBE (0220-1306-41)

0220- Boiron
- 0220-1307- Chininum sulphuricum
  - 0220-1307-41- 12 [hp_C] in 1 TUBE (0220-1307-41)

0220- Boiron
- 0220-1310- Chininum sulphuricum
  - 0220-1310-41- 15 [hp_C] in 1 TUBE (0220-1310-41)

0220- Boiron
- 0220-1311- Chininum sulphuricum
  - 0220-1311-41- 30 [hp_C] in 1 TUBE (0220-1311-41)

0220- Boiron
- 0220-1314- Chininum sulphuricum
  - 0220-1314-41- 200 [kp_C] in 1 TUBE (0220-1314-41)

0220- Boiron
- 0220-1325- Chininum sulphuricum
  - 0220-1325-41- 80 PELLET in 1 TUBE (0220-1325-41)

49708- Sun Pharmaceutical Industries, Inc.
- 49708-153- Qualaquin
  - 49708-153-07- 30 CAPSULE in 1 BOTTLE, PLASTIC (49708-153-07)

50742- Ingenus Pharmaceuticals, LLC
- 50742-238- QUININE SULFATE
  - 50742-238-30- 30 CAPSULE in 1 BOTTLE, PLASTIC (50742-238-30)

53489- Sun Pharmaceutical Industries, Inc.
- 53489-700- Quinine Sulfate
  - 53489-700-01- 100 CAPSULE in 1 BOTTLE, PLASTIC (53489-700-01)

53489- Sun Pharmaceutical Industries, Inc.
- 53489-700- Quinine Sulfate
  - 53489-700-07- 30 CAPSULE in 1 BOTTLE, PLASTIC (53489-700-07)

62106- Seroyal USA
- 62106-5706- CHININUM SULPHURICUM
  - 62106-5706-4- 10 TUBE in 1 CARTON (62106-5706-4) > 140 GRANULE in 1 TUBE

65162- Amneal Pharmaceuticals LLC
- 65162-811- Quinine Sulfate
  - 65162-811-03- 30 CAPSULE in 1 BOTTLE (65162-811-03)

65162- Amneal Pharmaceuticals LLC
- 65162-811- Quinine Sulfate
  - 65162-811-09- 90 CAPSULE in 1 BOTTLE (65162-811-09)

65162- Amneal Pharmaceuticals LLC
- 65162-811- Quinine Sulfate
  - 65162-811-50- 500 CAPSULE in 1 BOTTLE (65162-811-50)

68084- American Health Packaging
- 68084-947- Quinine Sulfate
  - 68084-947-32- 20 BLISTER PACK in 1 BOX, UNIT-DOSE (68084-947-32) > 1 CAPSULE in 1 BLISTER PACK (68084-947-33)

68180- Lupin Pharmaceuticals, Inc.
- 68180-560- QUININE SULFATE
  - 68180-560-01- 100 CAPSULE in 1 BOTTLE (68180-560-01)

68180- Lupin Pharmaceuticals, Inc.
- 68180-560- QUININE SULFATE
  - 68180-560-02- 500 CAPSULE in 1 BOTTLE (68180-560-02)

68180- Lupin Pharmaceuticals, Inc.
- 68180-560- QUININE SULFATE
  - 68180-560-03- 1000 CAPSULE in 1 BOTTLE (68180-560-03)

68180- Lupin Pharmaceuticals, Inc.
- 68180-560- QUININE SULFATE
  - 68180-560-06- 30 CAPSULE in 1 BOTTLE (68180-560-06)

68428- Washington Homeopathic Products
- 68428-308- Chininum purum
  - 68428-308-03- 75 PELLET in 1 VIAL, GLASS (68428-308-03)

68428- Washington Homeopathic Products
- 68428-308- Chininum purum
  - 68428-308-05- 150 PELLET in 1 VIAL, GLASS (68428-308-05)

68428- Washington Homeopathic Products
- 68428-308- Chininum purum
  - 68428-308-06- 1200 PELLET in 1 BOTTLE, GLASS (68428-308-06)

68428- Washington Homeopathic Products
- 68428-308- Chininum purum
  - 68428-308-11- 300 PELLET in 1 BOTTLE, GLASS (68428-308-11)

68428- Washington Homeopathic Products
- 68428-308- Chininum purum
  - 68428-308-12- 600 PELLET in 1 BOTTLE, GLASS (68428-308-12)

68428- Washington Homeopathic Products
- 68428-310- Chininum sulphuricum
  - 68428-310-03- 75 PELLET in 1 VIAL, GLASS (68428-310-03)

68428- Washington Homeopathic Products
- 68428-310- Chininum sulphuricum
  - 68428-310-05- 150 PELLET in 1 VIAL, GLASS (68428-310-05)

68428- Washington Homeopathic Products
- 68428-310- Chininum sulphuricum
  - 68428-310-06- 1200 PELLET in 1 BOTTLE, GLASS (68428-310-06)

68428- Washington Homeopathic Products
- 68428-310- Chininum sulphuricum
  - 68428-310-11- 300 PELLET in 1 BOTTLE, GLASS (68428-310-11)

68428- Washington Homeopathic Products
- 68428-310- Chininum sulphuricum
  - 68428-310-12- 600 PELLET in 1 BOTTLE, GLASS (68428-310-12)

71919- Washington Homeopathic Products
- 71919-187- Chininum purum
  - 71919-187-07- 15 mL in 1 VIAL, GLASS (71919-187-07)

71919- Washington Homeopathic Products
- 71919-187- Chininum purum
  - 71919-187-08- 30 mL in 1 VIAL, GLASS (71919-187-08)

71919- Washington Homeopathic Products
- 71919-187- Chininum purum
  - 71919-187-09- 50 mL in 1 BOTTLE, GLASS (71919-187-09)

71919- Washington Homeopathic Products
- 71919-187- Chininum purum
  - 71919-187-10- 100 mL in 1 BOTTLE, GLASS (71919-187-10)

71919- Washington Homeopathic Products
- 71919-189- Chininum sulphuricum
  - 71919-189-07- 15 mL in 1 VIAL, GLASS (71919-189-07)

71919- Washington Homeopathic Products
- 71919-189- Chininum sulphuricum
  - 71919-189-08- 30 mL in 1 VIAL, GLASS (71919-189-08)

71919- Washington Homeopathic Products
- 71919-189- Chininum sulphuricum
  - 71919-189-09- 50 mL in 1 BOTTLE, GLASS (71919-189-09)

71919- Washington Homeopathic Products
- 71919-189- Chininum sulphuricum
  - 71919-189-10- 100 mL in 1 BOTTLE, GLASS (71919-189-10)

section name header

Pronunciation ⬇

Classifications ⬆ ⬇

Indications ⬆ ⬇

Action ⬆ ⬇

Pharmacokinetics ⬆ ⬇

Time/Action Profile ⬆ ⬇

Contraind./Precautions ⬆ ⬇