Therapeutic Classification: lipid-lowering agents
Pharmacologic Classification: hmg coa reductase inhibitors (statin)
REMS
Absorption: 85% absorbed, but rapidly metabolized.
Distribution: Unknown.
Protein Binding: 95%.
Half-Life: Unknown.
Contraindicated in:
Use Cautiously in:
Endo: hyperglycemia
GI: abdominal cramps, constipation, diarrhea, flatus, heartburn, altered taste, drug-induced hepatitis, dyspepsia, ↑liver enzymes, nausea, pancreatitis
MS: RHABDOMYOLYSIS, arthralgia, immune-mediated necrotizing myopathy, myopathy (↑ risk with 80 mg dose)
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA)
Drug-drug:
The 80 mg dose should be restricted to patients who have been taking this dose for 12 mo without evidence of muscle toxicity
Renal Impairment
Generic
5 mg
45.97
90
10 mg
49.97
90
20 mg
73.97
90
40 mg
75.97
90
80 mg
89.97
90
5 mg; 10 mg; 20 mg; 40 mg; 80 mgLab Test Considerations:
NDC Code