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Pronunciation

am-LOE-di-peen

Classifications

Therapeutic Classification: antianginals, antihypertensives

Pharmacologic Classification: calcium channel blockers

Indications

REMS


Action

  • Inhibits the transport of calcium into myocardial and vascular smooth muscle cells, resulting in inhibition of excitation-contraction coupling and subsequent contraction.
Therapeutic effects:
  • Reduction in BP.
  • Decreased frequency and severity of attacks of angina.
  • Reduction in risk of hospitalization for angina or coronary revascularization in patients with recently documented coronary artery disease.

Pharmacokinetics

Absorption: Well absorbed after oral administration (64–90%).

Distribution: Probably crosses the placenta.

Protein Binding: 95–98%.

Metabolism/Excretion: Mostly metabolized by the liver by the CYP3A4 isoenzyme.

Half-Life: 30–50 hr ( in geriatric patients and patients with hepatic impairment).

Time/Action Profile

(cardiovascular effects)

ROUTEONSETPEAKDURATION
POunknown6–9 hr24 hr



Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: peripheral edema, angina, bradycardia, hypotension, palpitations

Derm: flushing

GI: gingival hyperplasia, nausea

Neuro: dizziness, fatigue

Interactions

Drug-drug:

Route/Dosage

Hepatic Impairment

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Katerzia, Norliqva, Norvasc

Pill Image

amlodipine-besylate_195-8896.jpg
amlodipine-besylate_195-8902.jpg

Code

NDC Code