Therapeutic Classification: antihypertensives
Pharmacologic Classification: adrenergics (centrally acting)
BEERS REMS
Absorption: Well absorbed from the GI tract and skin. Enters systemic circulation following epidural use.
Distribution: Widely distributed; enters CNS.
Half-Life: Neonates: 4472 hr; Children: 812 hr; Adults: Plasma: 1216 hr (↑ in renal impairment); CNS: 1.3 hr.
(PO, TD = antihypertensive effect; epidural = analgesia)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO | 3060 min | 13 hr | 812 hr |
Transdermal | 23 days | unknown | 7 days‡ |
Epidural | unknown | unknown | unknown |
‡8 hr following removal of patch.
Contraindicated in:
Use Cautiously in:
CV: bradycardia, heart block, hypotension (↑ with epidural), palpitations
Derm: rash, sweating
EENT: dry eyes
GI: dry mouth, constipation, nausea, vomiting
GU: ↓fertility, erectile dysfunction
Neuro: drowsiness, depression, dizziness, hallucinations, nervousness, nightmares, paresthesia
Drug-drug:
Hypertension
Attention-Deficit Hyperactivity Disorder
Cancer Pain
Opioid Withdrawal
Lab Test Considerations:
NDC Code