section name header

Pronunciation ⬇

ox-i-BYOO-ti-nin

Classifications ⬆ ⬇

Therapeutic Classification: urinary tract antispasmodics

Pharmacologic Classification: anticholinergics

Indications ⬆ ⬇

REMS

Action ⬆ ⬇

  • Inhibits the action of acetylcholine at postganglionic receptors.
  • Has direct spasmolytic action on smooth muscle, including smooth muscle lining the GU tract, without affecting vascular smooth muscle.
Therapeutic effects:
  • Increased bladder capacity.
  • Delayed desire to void.
  • Decreased urge incontinence, urinary urgency, and frequency and decreased number of urinary accidents associated with overactive bladder.

Pharmacokinetics ⬆ ⬇

Absorption: Rapidly absorbed following oral administration, but undergoes extensive first-pass metabolism; extended-release tablets provide extended release. Transdermal absorption occurs by passive diffusion through intact skin and bypasses the first-pass effect.

Distribution: Highly bound (>99%) to plasma proteins. Widely distributed.

Metabolism/Excretion: Extensively metabolized by the liver via the CYP3A4 isoenzyme; one metabolite is pharmacologically active; metabolites are renally excreted with negligible (<0.1%) excretion of unchanged drug.

Half-Life: 7–8 hr (oral and patch); 30–64 hr (gel).

Time/Action Profile ⬆ ⬇

(urinary spasmolytic effect)

ROUTEONSETPEAKDURATION
PO30–60 min3–6 hr6–10 hr (up to 24 hr with XL tablet)
TD-patchwithin 24 hr36 hr3–4 days



Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: chest pain, edema, tachycardia

Derm: ↓sweating, transdermal only: application site reactions, hot flushes, pruritus

EENT: blurred vision, hoarseness

GI: constipation, dry mouth, nausea, abdominal pain, anorexia, diarrhea, dysphagia

GU: urinary retention, ↑thirst

Metab: hyperthermia

Neuro: dizziness, drowsiness, agitation, confusion, hallucinations, headache

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA)

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

oxyBUTYnin (oral): Ditropan, Ditropan XL,

oxyBUTYnin (transdermal gel): Gelnique,

oxyBUTYnin (transdermal patch): Oxytrol, Oxytrol for Women

Code ⬆

NDC Code