section name header

Pronunciation ⬇

e-ZET-i-mibe

Classifications ⬆ ⬇

Therapeutic Classification: lipid-lowering agents

Pharmacologic Classification: cholesterol absorption inhibitors

Indications ⬆ ⬇

REMS

Action ⬆ ⬇

  • Inhibits absorption of cholesterol in the small intestine.
Therapeutic effects:
  • Reduction of LDL-C concentrations.
  • Reduction of sitosterol and campesterol concentrations.

Pharmacokinetics ⬆ ⬇

Absorption: Following absorption, rapidly converted to ezetimibe-glucuronide, which is active. Bioavailability is variable.

Distribution: Unknown.

Metabolism/Excretion: Undergoes enterohepatic recycling, mostly eliminated in feces, minimal renal excretion.

Half-Life: 22 hr.

Time/Action Profile ⬆ ⬇

ROUTEONSETPEAKDURATION
POunknownunknownunknown



Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: rash

GI: ↑liver enzymes, cholecystitis, cholelithiasis, nausea, pancreatitis

MS: myopathy, RHABDOMYOLYSIS

Misc: ANGIOEDEMA

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Renal Impairment

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Zetia

Canadian Brand Names ⬆ ⬇

Ezetrol

Pill Image

ezetimibe_195-8834.jpg

Code ⬆

NDC Code