IV Administration:

• Administer a non-sedating antihistamine 30–60 min prior to start of infusion.
• Intermittent Infusion: Allow vials to reach room temperature before diluting; do not heat, microwave, or shake. Solution is clear and colorless to slightly yellow; may have thin translucent fibers. Do not administer solutions that are discolored or contain particulate matter. Use an 18 gauge needle to slowly remove dose from vials to avoid agitation, turbulence, or bubbles. Slowly add solution to empty infusion bag. Add 0.9% NaCl equal to volume of medication. Gently rock bag to mix; do not shake.
• Rate: Infuse via in-line, low-protein binding 0.2 micron filter over 4 hr. Infuse first 2.5% of total volume over first hr. Account for dead space in lines to ensure 2.5% of total infusion volume is delivered into patient’s bloodstream during 1st hr of infusion. Then increase infusion rate as tolerated to complete infusion over following 3 hrs. Do not flush line to prevent rapid bolus of medication. May add 0.9% NaCl through y-site or piggyback to maintain flow and prevent clotting or line blockage. Complete infusion within 42 hr of dilution. Solution is stable for 6 hr at room temperature or 36 hr if refrigerated.
• Y-Site Incompatibility: Do not administer other products through infusion tubing.