Contraindicated in:
Use Cautiously in:
CV: arrhythmias, hypotension.
Derm: alopecia.
F and E: electrolyte imbalance.
GI: abdominal pain, abnormal taste, anorexia, constipation, diarrhea, gi bleed, gi perforation, nausea, vomiting, dyspepsia, ENTEROCOLITIS, ILEUS.
GU: hematuria, cystitis, RENAL FAILURE.
Hemat: anemia, leukopenia, neutropenia, thrombocytopenia.
MS: arthralgia, back pain, muscle spasms.
Neuro: peripheral neuropathy, weakness, fatigue.
Resp: dyspnea, ACUTE RESPIRATORY DISTRESS SYNDROME, INTERSTITIAL LUNG DISEASE.
Misc: fever, HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS).
Drug-Drug:
Drug-Natural Products:
(Generic available)
Hepatic Impairment
Absorption: IV administration results in complete bioavailability.
Distribution: Equally distributed between blood and plasma.
Metabolism/Excretion: Extensively (>95%) metabolized by the liver, 8090% by the CYP3A4/5 isoenzymes. Metabolites are excreted in urine and feces. Minimal renal excretion.
Half-life: 95 hr.
NDC Code*