fen-oh-PROE-fen 
Contraindicated in:
Use Cautiously in:
CV: HF, MYOCARDIAL INFARCTION, STROKE, edema, palpitations.
Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), pruritus, rash, sweating.
EENT: blurred vision, hearing loss, tinnitus.
F and E: hyperkalemia.
GI: GI BLEEDING, HEPATITIS, dyspepsia, abdominal pain, constipation, diarrhea, discomfort, nausea, vomiting.
GU: cystitis, dysuria, hematuria, renal failure.
Hemat: prolonged bleeding time.
Drug-Drug:
Drug-Natural Products:
Rheumatoid Arthritis/Osteoarthritis
Mild-to-Moderate Pain
Therapeutic Classification: antirheumatics, nonopioid analgesics
Pharmacologic Classification: propionic acid derivatives, nonsteroidal anti-inflammatory drugs (NSAIDs)
Absorption: Well absorbed from the GI tract.
Distribution: Enters breast milk in low concentrations.
Protein Binding: >99%.
Metabolism/Excretion: Mostly metabolized by the liver. 2–5% excreted unchanged by the kidneys.
Half-life: 3 hr.
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO (analgesic activity) | 15–30 min | 1–2 hr | 4–6 hr |
| PO (anti-inflammatory activity) | several days | 2–3 wk | unknown |
NDC Code*