- PO (Adults): Short-term treatment of active ulcers: 300 mg 4 times daily or 800 mg at bedtime or 400–600 mg twice daily (not to exceed 2.4 g/day). Duodenal ulcer prophylaxis: 300 mg twice daily or 400 mg at bedtime. GERD: 800–1600 mg/day in divided doses. Gastric hypersecretory conditions: 300–600 mg every 6 hr (up to 12 g/day have been used). OTC use: up to 200 mg may be taken twice daily (for no more than 2 wk).
- PO (Children): Short-term treatment of active ulcers: 20–40 mg/kg/day in 4 divided doses.
Renal Impairment
- PO (Adults): 300 mg every 8–12 hr; further adjustment may be required for concurrent hepatic impairment.
- PO (Children): 10–15 mg/kg/day given in divided doses every 8–12 hr.
