byoo-SPYE-rone 
Contraindicated in:
Use Cautiously in:
CV: chest pain, palpitations, tachycardia, hypertension, hypotension, syncope.
Derm: rash, sweating, alopecia, blisters, bruising, dry skin, edema, flushing, pruritus.
EENT: blurred vision, nasal congestion, sore throat, tinnitus, altered taste or smell, conjunctivitis.
Endo: irregular menses.
GI: nausea, abdominal pain, constipation, diarrhea, dry mouth, vomiting.
GU: changes in libido, dysuria, urinary frequency, urinary hesitancy.
MS: myalgia.
Neuro: dizziness, drowsiness, excitement, fatigue, headache, incoordination, insomnia, nervousness, numbness, paresthesia, weakness, personality changes, tremor.
Resp: chest congestion, hyperventilation, shortness of breath.
Misc: clamminess, fever.
Drug-Drug:
Drug-Natural Products:
Drug-Food:
Absorption: Rapidly absorbed.
Distribution: Widely distributed to tissues.
Protein Binding: 95%.
Metabolism/Excretion: Extensively metabolized by the liver via the CYP3A4 isoenzyme; 20–40% excreted in feces.
Half-life: 2–3 hr.
NDC Code*