Contraindicated in:
Use Cautiously in:
CV: hypotension.
Endo: hypoglycemia (↑ with other medications).
F and E: hypermagnesemia, hyperphosphatemia, KETOACIDOSIS, thirst.
GI: abdominal pain, constipation, nausea.
GU: female mycotic infections, ↓ renal function, ↑ urination, acute kidney injury, glucosuria, male mycotic infections, NECROTIZING FASCIITIS OF PERINEUM (FOURNIER'S GANGRENE), urinary tract infection (including pyelonephritis), UROSEPSIS, vulvovaginal pruritus.
Metab: hyperlipidemia.
MS: bone fractures, lower limb amputation.
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS OR ANGIOEDEMA).
Drug-Drug:
Renal Impairment
Therapeutic Classification: antidiabetics
Pharmacologic Classification: sodium-glucose co-transporter 2 (SGLT2) inhibitors
Absorption: Well absorbed (65%) following oral administration.
Distribution: Extensive tissue distribution.
Protein Binding: 99%.
Metabolism/Excretion: Mostly metabolized by UDP-glucuronyl transferases (UGT) to inactive metabolites, minimal metabolism by CYP3A4 (7%). 50% excreted in feces as parent drug and metabolites, 33% as metabolites in urine, <1% excreted in urine as unchanged drug.
Half-life: 10.6 hr.
NDC Code*