Contraindicated in:
Use Cautiously in:
Reflects combination therapy
Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), rash (may progress to toxic epidermal necrolysis), STEVENS-JOHNSON SYNDROME.
GI: HEPATOTOXICITY, ↑liver enzymes, nausea, abdominal pain, diarrhea, hepatitis, ulcerative stomatitis.
GU: ↓fertility (females).
Hemat: granulocytopenia (↑ in children).
MS: myalgia.
Neuro: paresthesia, peripheral neuropathy , headache.
Misc: fever, immune reconstitution syndrome.
Drug-Drug:
Drug-Natural Products:
(Generic available)
Therapeutic Classification: antiretrovirals
Pharmacologic Classification: non nucleoside reverse transcriptase inhibitors
Absorption: >90% absorbed after oral administration.
Distribution: Crosses placenta and enters breast milk; CSF levels are 45% of those in plasma.
Metabolism/Excretion: Mostly metabolized by the liver (CYP3A4 enzyme system); minor amounts excreted unchanged in urine.
Half-life: 2530 hr (during multiple dosing).
NDC Code*