section name header

Indications ⬇

REMS

Mycophenolate mofetil:

Mycophenolic acid:

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: edema, hypertension, hypotension, tachycardia.

Derm: rash.

Endo: hyperglycemia.

F and E: hyperkalemia, hypocalcemia, hypokalemia, hypomagnesemia.

GI: anorexia, constipation, diarrhea, nausea, vomiting, abdominal pain, GI BLEEDING.

GU: renal impairment.

Hemat: leukocytosis, leukopenia, thrombocytopenia, anemia, pure red cell aplasia.

Metab: hypercholesterolemia.

Neuro: anxiety, confusion, dizziness, headache, insomnia, paresthesia, sedation, tremor, PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY (PML).

Resp: cough, dyspnea.

Misc: fever, infection (including activation of latent viral infections such as Polyomavirus-associated nephropathy or Hepatitis B/C), acute inflammatory syndrome, MALIGNANCY.

Interactions ⬆ ⬇

Drug-Drug:

Availability ⬆ ⬇

(Generic available)

Mycophenolate Mofetil

Mycophenolic Acid

Route/Dosage ⬆ ⬇

Mycophenolate Mofetil

Kidney Transplantation

Renal Impairment

Mycophenolic Acid

Mycophenolate mofetil and mycophenolic acid should not be used interchangeably without the advice of a health care professional.

Kidney Transplantation

US Brand Names ⬆ ⬇

CellCept

mycophenolic acid: Myfortic

Action ⬆ ⬇

Therapeutic Effects:

Classifications ⬆ ⬇

Therapeutic Classification: Immunosuppressant agents

Pharmacokinetics ⬆ ⬇

Absorption: Following oral and IV administration, mycophenolate mofetil is rapidly hydrolyzed to mycophenolic acid (MPA), the active metabolite. Absorption of enteric-coated mycophenolic acid (Myfortic) is delayed compared with mycophenolate mofetil (CellCept).

Distribution: Cross the placenta and enter breast milk.

Protein Binding: MPA: 97%.

Metabolism/Excretion: MPA is extensively metabolized; <1% excreted unchanged in urine. Some enterohepatic recirculation of MPA occurs.

Half-life: MPA: 8–18 hr.

Time/Action Profile ⬆ ⬇

(blood levels of MPA)

ROUTEONSETPEAKDURATION
mycophenolate mofetil-POrapid0.25–1.25 hrN/A
mycophenolic acidrapid1.5–2.75 hrN/A

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

mye-koe-FEE-noe-late MOE-fe-til

mycophenolic acid: mye-koe-FEE-noe-lik

Code ⬆

NDC Code*