ranolazine

REMS

Chronic angina pectoris.

Contraindicated in:

Hypersensitivity;
Concurrent use of strong CYP3A inhibitors;
Concurrent use of CYP3A inducers;
Hepatic impairment;
Lactation: Lactation.

Use Cautiously in:

Renal impairment;
OB: Use during pregnancy only if potential maternal benefit justifies potential fetal risk;
Pedi: Safety and effectiveness not established in children;
Geri: ↑risk of adverse reactions in patients >75 yr.

CV: palpitations, QT interval prolongation, TORSADES DE POINTES

EENT: tinnitus

GI: abdominal pain, constipation, dry mouth, nausea, vomiting

GU: acute renal failure

Neuro: dizziness, headache

Drug-drug:

Ketoconazole, itraconazole, clarithromycin, nefazodone, nelfinavir, and ritonavir significantly ↑ levels and risk of toxicity; concurrent use contraindicated.
Rifampin, rifabutin, rifapentin, phenobarbital, phenytoin, and carbamazepine significantly ↓ levels and effectiveness; concurrent use contraindicated.
Verapamil, diltiazem, aprepitant, erythromycin, and fluconazole may ↑ levels and risk of toxicity; do not exceed ranolazine dose of 500 mg twice daily.
Cyclosporine and paroxetine may ↑ levels and risk of toxicity.
May ↑ levels and risk of toxicity of simvastatin, metoprolol, tricyclic antidepressants, and antipsychotics.
May ↑ digoxin levels and risk of toxicity; dose adjustment may be required.

Drug-Natural Products:

St. John's wort significantly ↓ levels and effectiveness; concurrent use contraindicated.

Drug-Food:

Grapefruit juice↑ levels and risk of toxicity; do not exceed ranolazine dose of 500 mg twice daily.

(Generic available)

Extended-release tablets: 500 mg; 1000 mg

PO (Adults ): 500 mg twice daily initially; may ↑ to 1000 mg twice daily.

~~Ranexa~~

Does not ↓ BP or heart rate; remainder of mechanism is not known.

Therapeutic effects:

Decreased frequency of angina.

Therapeutic Classification: antianginals

Absorption: Highly variable.

Distribution: Unknown.

Metabolism/Excretion: Metabolized by the liver primarily by the CYP3A isoenzyme and to a lesser extent by the CYP2D6 isoenzyme; <5% excreted unchanged in urine and feces.

Half-Life: 7 hr.

Corzyna

(plasma concentrations)

ROUTE	ONSET	PEAK	DURATION
PO	unknown	2–5 hr	12 hr

Explain purpose and side effects of medication to patient. Advise to read Patient Information before starting therapy.
If dose is missed, instruct patient to take the usual dose at the next scheduled time; do not double doses. Explain that ranolazine is used for chronic therapy and will not help an acute angina episode.
Advise patient to avoid grapefruit juice and grapefruit products when taking ranolazine.
May cause dizziness and light-headedness. Caution patient to avoid driving and other activities requiring alertness until response to medication is known.
Advise patient to notify health care professional if fainting occurs.
Inform patient that ranolazine may cause changes in the ECG. Patient should inform health care professional if they have a personal or family history of QTc interval prolongation, congenital long QT syndrome, or proarrhythmic conditions such as hypokalemia.
Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and consult health care professional before taking any new medications.
Rep: Advise women of reproductive potential to notify health care professional if pregnancy is planned or suspected, or if breastfeeding.

ra-NOLE-a-zeen

NDC Code

27241- Ajanta Pharma Limited
- 27241-125- Ranolazine
  - 27241-125-02- 60 TABLET, EXTENDED RELEASE in 1 BOTTLE (27241-125-02)

27241- Ajanta Pharma Limited
- 27241-126- Ranolazine
  - 27241-126-02- 60 TABLET, EXTENDED RELEASE in 1 BOTTLE (27241-126-02)

43353- Aphena Pharma Solutions - Tennessee, LLC
- 43353-880- Ranexa
  - 43353-880-83- 3600 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (43353-880-83)

43975- Amerigen Pharmaceuticals Inc.
- 43975-289- Ranolazine
  - 43975-289-06- 60 TABLET, EXTENDED RELEASE in 1 BOTTLE (43975-289-06)

43975- Amerigen Pharmaceuticals Inc.
- 43975-289- Ranolazine
  - 43975-289-50- 500 TABLET, EXTENDED RELEASE in 1 BOTTLE (43975-289-50)

43975- Amerigen Pharmaceuticals Inc.
- 43975-290- Ranolazine
  - 43975-290-06- 60 TABLET, EXTENDED RELEASE in 1 BOTTLE (43975-290-06)

43975- Amerigen Pharmaceuticals Inc.
- 43975-290- Ranolazine
  - 43975-290-50- 500 TABLET, EXTENDED RELEASE in 1 BOTTLE (43975-290-50)

45963- Actavis Pharma, Inc.
- 45963-418- Ranolazine
  - 45963-418-06- 60 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (45963-418-06)

45963- Actavis Pharma, Inc.
- 45963-418- Ranolazine
  - 45963-418-50- 500 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (45963-418-50)

45963- Actavis Pharma, Inc.
- 45963-419- Ranolazine
  - 45963-419-06- 60 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (45963-419-06)

45963- Actavis Pharma, Inc.
- 45963-419- Ranolazine
  - 45963-419-50- 500 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (45963-419-50)

50228- ScieGen Pharmaceuticals, Inc
- 50228-423- RANOLAZINE
  - 50228-423-05- 500 TABLET, FILM COATED, EXTENDED RELEASE in 1 PACKAGE (50228-423-05)

50228- ScieGen Pharmaceuticals, Inc
- 50228-423- RANOLAZINE
  - 50228-423-30- 30 TABLET, FILM COATED, EXTENDED RELEASE in 1 PACKAGE (50228-423-30)

50228- ScieGen Pharmaceuticals, Inc
- 50228-423- RANOLAZINE
  - 50228-423-60- 60 TABLET, FILM COATED, EXTENDED RELEASE in 1 PACKAGE (50228-423-60)

50228- ScieGen Pharmaceuticals, Inc
- 50228-424- RANOLAZINE
  - 50228-424-05- 500 TABLET, FILM COATED, EXTENDED RELEASE in 1 PACKAGE (50228-424-05)

50228- ScieGen Pharmaceuticals, Inc
- 50228-424- RANOLAZINE
  - 50228-424-30- 30 TABLET, FILM COATED, EXTENDED RELEASE in 1 PACKAGE (50228-424-30)

50228- ScieGen Pharmaceuticals, Inc
- 50228-424- RANOLAZINE
  - 50228-424-60- 60 TABLET, FILM COATED, EXTENDED RELEASE in 1 PACKAGE (50228-424-60)

51407- Golden State Medical Supply Inc.
- 51407-225- RANOLAZINE
  - 51407-225-60- 60 TABLET, FILM COATED, EXTENDED RELEASE in 1 PACKAGE (51407-225-60)

51407- Golden State Medical Supply Inc.
- 51407-226- RANOLAZINE
  - 51407-226-60- 60 TABLET, FILM COATED, EXTENDED RELEASE in 1 PACKAGE (51407-226-60)

61958- Gilead Sciences, Inc.
- 61958-1003- Ranexa
  - 61958-1003-1- 60 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (61958-1003-1)

61958- Gilead Sciences, Inc.
- 61958-1003- Ranexa
  - 61958-1003-2- 14 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (61958-1003-2)

61958- Gilead Sciences, Inc.
- 61958-1003- Ranexa
  - 61958-1003-3- 14 TABLET, FILM COATED, EXTENDED RELEASE in 1 BLISTER PACK (61958-1003-3)

61958- Gilead Sciences, Inc.
- 61958-1004- Ranexa
  - 61958-1004-1- 60 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (61958-1004-1)

61958- Gilead Sciences, Inc.
- 61958-1004- Ranexa
  - 61958-1004-2- 14 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (61958-1004-2)

61958- Gilead Sciences, Inc.
- 61958-1004- Ranexa
  - 61958-1004-3- 14 TABLET, FILM COATED, EXTENDED RELEASE in 1 BLISTER PACK (61958-1004-3)

63304- Sun Pharmaceutical Industries, Inc.
- 63304-017- Ranolazine
  - 63304-017-05- 500 TABLET, EXTENDED RELEASE in 1 BOTTLE (63304-017-05)

63304- Sun Pharmaceutical Industries, Inc.
- 63304-017- Ranolazine
  - 63304-017-28- 180 TABLET, EXTENDED RELEASE in 1 BOTTLE (63304-017-28)

63304- Sun Pharmaceutical Industries, Inc.
- 63304-017- Ranolazine
  - 63304-017-60- 60 TABLET, EXTENDED RELEASE in 1 BOTTLE (63304-017-60)

63304- Sun Pharmaceutical Industries, Inc.
- 63304-018- Ranolazine
  - 63304-018-05- 500 TABLET, EXTENDED RELEASE in 1 BOTTLE (63304-018-05)

63304- Sun Pharmaceutical Industries, Inc.
- 63304-018- Ranolazine
  - 63304-018-28- 180 TABLET, EXTENDED RELEASE in 1 BOTTLE (63304-018-28)

63304- Sun Pharmaceutical Industries, Inc.
- 63304-018- Ranolazine
  - 63304-018-60- 60 TABLET, EXTENDED RELEASE in 1 BOTTLE (63304-018-60)

68180- Lupin Pharmaceuticals, Inc.
- 68180-354- RANOLAZINE
  - 68180-354-02- 500 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (68180-354-02)

68180- Lupin Pharmaceuticals, Inc.
- 68180-354- RANOLAZINE
  - 68180-354-07- 60 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (68180-354-07)

68180- Lupin Pharmaceuticals, Inc.
- 68180-355- RANOLAZINE
  - 68180-355-02- 500 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (68180-355-02)

68180- Lupin Pharmaceuticals, Inc.
- 68180-355- RANOLAZINE
  - 68180-355-07- 60 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (68180-355-07)

68462- Glenmark Pharmaceuticals Inc., USA
- 68462-319- Ranolazine
  - 68462-319-05- 500 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (68462-319-05)

68462- Glenmark Pharmaceuticals Inc., USA
- 68462-319- Ranolazine
  - 68462-319-60- 60 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (68462-319-60)

68462- Glenmark Pharmaceuticals Inc., USA
- 68462-320- Ranolazine
  - 68462-320-05- 500 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (68462-320-05)

68462- Glenmark Pharmaceuticals Inc., USA
- 68462-320- Ranolazine
  - 68462-320-60- 60 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (68462-320-60)

69097- Cipla USA Inc.
- 69097-221- Ranolazine
  - 69097-221-02- 30 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (69097-221-02)

69097- Cipla USA Inc.
- 69097-221- Ranolazine
  - 69097-221-03- 60 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (69097-221-03)

69097- Cipla USA Inc.
- 69097-221- Ranolazine
  - 69097-221-12- 500 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (69097-221-12)

69097- Cipla USA Inc.
- 69097-222- Ranolazine
  - 69097-222-02- 30 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (69097-222-02)

69097- Cipla USA Inc.
- 69097-222- Ranolazine
  - 69097-222-03- 60 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (69097-222-03)

69097- Cipla USA Inc.
- 69097-222- Ranolazine
  - 69097-222-12- 500 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (69097-222-12)

70771- Cadila Healthcare Limited
- 70771-1499- Ranolazine
  - 70771-1499-1- 100 TABLET, EXTENDED RELEASE in 1 BOTTLE (70771-1499-1)

70771- Cadila Healthcare Limited
- 70771-1499- Ranolazine
  - 70771-1499-4- 10 BLISTER PACK in 1 CARTON (70771-1499-4) > 10 TABLET, EXTENDED RELEASE in 1 BLISTER PACK (70771-1499-2)

70771- Cadila Healthcare Limited
- 70771-1499- Ranolazine
  - 70771-1499-5- 500 TABLET, EXTENDED RELEASE in 1 BOTTLE (70771-1499-5)

70771- Cadila Healthcare Limited
- 70771-1499- Ranolazine
  - 70771-1499-6- 60 TABLET, EXTENDED RELEASE in 1 BOTTLE (70771-1499-6)

70771- Cadila Healthcare Limited
- 70771-1500- Ranolazine
  - 70771-1500-1- 100 TABLET, EXTENDED RELEASE in 1 BOTTLE (70771-1500-1)

70771- Cadila Healthcare Limited
- 70771-1500- Ranolazine
  - 70771-1500-4- 10 BLISTER PACK in 1 CARTON (70771-1500-4) > 10 TABLET, EXTENDED RELEASE in 1 BLISTER PACK (70771-1500-2)

70771- Cadila Healthcare Limited
- 70771-1500- Ranolazine
  - 70771-1500-5- 500 TABLET, EXTENDED RELEASE in 1 BOTTLE (70771-1500-5)

70771- Cadila Healthcare Limited
- 70771-1500- Ranolazine
  - 70771-1500-6- 60 TABLET, EXTENDED RELEASE in 1 BOTTLE (70771-1500-6)

71610- Aphena Pharma Solutions - Tennessee, LLC
- 71610-322- RANOLAZINE
  - 71610-322-83- 3600 TABLET, FILM COATED, EXTENDED RELEASE in 1 PACKAGE (71610-322-83)

72578- Viona Pharmaceuticals Inc
- 72578-064- Ranolazine
  - 72578-064-01- 100 TABLET, EXTENDED RELEASE in 1 BOTTLE (72578-064-01)

72578- Viona Pharmaceuticals Inc
- 72578-064- Ranolazine
  - 72578-064-05- 500 TABLET, EXTENDED RELEASE in 1 BOTTLE (72578-064-05)

72578- Viona Pharmaceuticals Inc
- 72578-064- Ranolazine
  - 72578-064-14- 60 TABLET, EXTENDED RELEASE in 1 BOTTLE (72578-064-14)

72578- Viona Pharmaceuticals Inc
- 72578-064- Ranolazine
  - 72578-064-77- 10 BLISTER PACK in 1 CARTON (72578-064-77) > 10 TABLET, EXTENDED RELEASE in 1 BLISTER PACK (72578-064-30)

72578- Viona Pharmaceuticals Inc
- 72578-065- Ranolazine
  - 72578-065-01- 100 TABLET, EXTENDED RELEASE in 1 BOTTLE (72578-065-01)

72578- Viona Pharmaceuticals Inc
- 72578-065- Ranolazine
  - 72578-065-05- 500 TABLET, EXTENDED RELEASE in 1 BOTTLE (72578-065-05)

72578- Viona Pharmaceuticals Inc
- 72578-065- Ranolazine
  - 72578-065-14- 60 TABLET, EXTENDED RELEASE in 1 BOTTLE (72578-065-14)

72578- Viona Pharmaceuticals Inc
- 72578-065- Ranolazine
  - 72578-065-77- 10 BLISTER PACK in 1 CARTON (72578-065-77) > 10 TABLET, EXTENDED RELEASE in 1 BLISTER PACK (72578-065-30)

section name header

Indications ⬇

Contraind./Precautions ⬆ ⬇

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Classifications ⬆ ⬇

Pharmacokinetics ⬆ ⬇

Canadian Brand Names ⬆ ⬇

Time/Action Profile ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

Code ⬆