dipyridamole

section name header

Indications ⬇

REMS

As an alternative to exercise in myocardial perfusion scintigraphy (cardiac stress testing with radiotracer imaging).

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Hypersensitivity.

Use Cautiously in:

Hypotension;
Patients with platelet defects;
OB: Use during pregnancy only if potential maternal benefit justifies potential fetal risk;
Lactation: Use while breastfeeding only if potential maternal benefit justifies potential risk to infant;
Pedi: Children <6 yr (safety and effectiveness not established);

Adv. Reactions/Side Effects ⬆ ⬇

CV: hypotension, arrhythmias, flushing, MI

GI: nausea, diarrhea, GI upset, vomiting

Derm: rash

Neuro: dizziness, headache, syncope, transient cerebral ischemia, weakness

Resp: bronchospasm

Interactions ⬆ ⬇

Drug-drug:

Anticoagulants, thrombolytic agents, NSAIDs, cefotetan, or valproic acid may ↑ risk of bleeding.
↑risk of hypotension with alcohol.
Theophylline may ↓ effectiveness.

Availability ⬆ ⬇

(Generic available)

Solution for injection: 5 mg/mL
In combination with:
aspirin.

Route/Dosage ⬆ ⬇

IV (Adults ): 570 mcg/kg (max dose = 60 mg).

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Produces coronary vasodilation by inhibiting adenosine uptake.

Therapeutic effects:

In diagnostic thallium imaging, dipyridamole dilates normal coronary arteries, reducing flow to vessels that are narrowed and causing abnormal thallium distribution.

Classifications ⬆ ⬇

Therapeutic Classification: antiplatelet agents, diagnostic agents (coronary vasodilators)

Pharmacologic Classification: platelet adhesion inhibitors

Pharmacokinetics ⬆ ⬇

Absorption: IV administration results in complete bioavailability.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Metabolized by the liver; excreted in the bile.

Half-Life: 10 hr.

Canadian Brand Names ⬆ ⬇

Persantine

Time/Action Profile ⬆ ⬇

(coronary vasodilation)

ROUTE	ONSET	PEAK	DURATION
IV	unknown	6.5 min	30 min

Patient/Family Teaching ⬆ ⬇

Explain purpose and side effects of medication. Advise patient to read Patient Information before starting therapy.
- Advise patient to consult health care professional before taking OTC medications concurrently with this medication.
- Advise patient to avoid the use of alcohol, as it may potentiate hypotensive effects. Tobacco products should also be avoided because nicotine causes vasoconstriction.
- Caution patient to change positions slowly to minimize orthostatic hypotension.
- Instruct patient to notify health care professional if unusual bleeding or bruising occurs. .
Rep: Advise women of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Pronunciation ⬆ ⬇

dye-peer-ID-a-mole

Code ⬆

NDC Code

0115- Amneal Pharmaceuticals of New York LLC
- 0115-1070- Dipyridamole
  - 0115-1070-01- 100 TABLET in 1 BOTTLE (0115-1070-01)

0115- Amneal Pharmaceuticals of New York LLC
- 0115-1071- Dipyridamole
  - 0115-1071-01- 100 TABLET in 1 BOTTLE (0115-1071-01)

0115- Amneal Pharmaceuticals of New York LLC
- 0115-1072- Dipyridamole
  - 0115-1072-01- 100 TABLET in 1 BOTTLE (0115-1072-01)

0404- Henry Schein, Inc.
- 0404-9852- Dipyridamole
  - 0404-9852-10- 1 VIAL, SINGLE-DOSE in 1 BAG (0404-9852-10) / 10 mL in 1 VIAL, SINGLE-DOSE

0641- Hikma Pharmaceuticals USA Inc.
- 0641-2569- Dipyridamole
  - 0641-2569-44- 5 VIAL in 1 CARTON (0641-2569-44) / 10 mL in 1 VIAL (0641-2569-41)

12660- Societa Italiana Medicinali Scandicci S.I.M.S., SrL
- 12660-0084-
  - 12660-0084-1- 25 kg in 1 DRUM (12660-0084-1)

17511- COHANCE LIFESCIENCES LIMITED
- 17511-122-
  - 17511-122-06- 1 kg in 1 DRUM (17511-122-06)

51662- HF Acquisition Co LLC, DBA HealthFirst
- 51662-1447- DIPYRIDAMOLE
  - 51662-1447-1- 10 mL in 1 VIAL (51662-1447-1)

51927- Professional Compounding Centers of America dba PCCA
- 51927-1571-
  - 51927-1571-0- 1 kg in 1 CONTAINER (51927-1571-0)

65015- Mylan Laboratories Limited
- 65015-782-
  65015-782-61- 100 kg in 1 DRUM (65015-782-61)

65404- AGC Pharma Chemicals Europe, S.L.U.
- 65404-005-
  65404-005-01- 35000000 mg in 1 DRUM (65404-005-01)

65841- Zydus Lifesciences Limited
- 65841-662- Dipyridamole
  65841-662-01- 100 TABLET, FILM COATED in 1 BOTTLE (65841-662-01)

65841- Zydus Lifesciences Limited
- 65841-662- Dipyridamole
  - 65841-662-05- 500 TABLET, FILM COATED in 1 BOTTLE (65841-662-05)

65841- Zydus Lifesciences Limited
- 65841-662- Dipyridamole
  - 65841-662-10- 1000 TABLET, FILM COATED in 1 BOTTLE (65841-662-10)

65841- Zydus Lifesciences Limited
- 65841-662- Dipyridamole
  - 65841-662-77- 10 BLISTER PACK in 1 CARTON (65841-662-77) / 10 TABLET, FILM COATED in 1 BLISTER PACK

65841- Zydus Lifesciences Limited
- 65841-663- Dipyridamole
  - 65841-663-01- 100 TABLET, FILM COATED in 1 BOTTLE (65841-663-01)

65841- Zydus Lifesciences Limited
- 65841-663- Dipyridamole
  - 65841-663-05- 500 TABLET, FILM COATED in 1 BOTTLE (65841-663-05)

65841- Zydus Lifesciences Limited
- 65841-663- Dipyridamole
  - 65841-663-10- 1000 TABLET, FILM COATED in 1 BOTTLE (65841-663-10)

65841- Zydus Lifesciences Limited
- 65841-663- Dipyridamole
  - 65841-663-77- 10 BLISTER PACK in 1 CARTON (65841-663-77) / 10 TABLET, FILM COATED in 1 BLISTER PACK

65841- Zydus Lifesciences Limited
- 65841-664- Dipyridamole
  - 65841-664-01- 100 TABLET, FILM COATED in 1 BOTTLE (65841-664-01)

65841- Zydus Lifesciences Limited
- 65841-664- Dipyridamole
  - 65841-664-05- 500 TABLET, FILM COATED in 1 BOTTLE (65841-664-05)

65841- Zydus Lifesciences Limited
- 65841-664- Dipyridamole
  - 65841-664-10- 1000 TABLET, FILM COATED in 1 BOTTLE (65841-664-10)

65841- Zydus Lifesciences Limited
- 65841-664- Dipyridamole
  - 65841-664-77- 10 BLISTER PACK in 1 CARTON (65841-664-77) / 10 TABLET, FILM COATED in 1 BLISTER PACK

66039- Glenmark Life Sciences Limited
- 66039-917-
  - 66039-917-04- 50 kg in 1 DRUM (66039-917-04)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-187- Dipyridamole
  68382-187-01- 100 TABLET, FILM COATED in 1 BOTTLE (68382-187-01)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-187- Dipyridamole
  - 68382-187-05- 500 TABLET, FILM COATED in 1 BOTTLE (68382-187-05)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-187- Dipyridamole
  - 68382-187-10- 1000 TABLET, FILM COATED in 1 BOTTLE (68382-187-10)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-187- Dipyridamole
  - 68382-187-77- 10 BLISTER PACK in 1 CARTON (68382-187-77) / 10 TABLET, FILM COATED in 1 BLISTER PACK

68382- Zydus Pharmaceuticals USA Inc.
- 68382-188- Dipyridamole
  - 68382-188-01- 100 TABLET, FILM COATED in 1 BOTTLE (68382-188-01)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-188- Dipyridamole
  - 68382-188-05- 500 TABLET, FILM COATED in 1 BOTTLE (68382-188-05)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-188- Dipyridamole
  - 68382-188-10- 1000 TABLET, FILM COATED in 1 BOTTLE (68382-188-10)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-188- Dipyridamole
  - 68382-188-77- 10 BLISTER PACK in 1 CARTON (68382-188-77) / 10 TABLET, FILM COATED in 1 BLISTER PACK

68382- Zydus Pharmaceuticals USA Inc.
- 68382-189- Dipyridamole
  - 68382-189-01- 100 TABLET, FILM COATED in 1 BOTTLE (68382-189-01)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-189- Dipyridamole
  - 68382-189-05- 500 TABLET, FILM COATED in 1 BOTTLE (68382-189-05)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-189- Dipyridamole
  - 68382-189-10- 1000 TABLET, FILM COATED in 1 BOTTLE (68382-189-10)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-189- Dipyridamole
  - 68382-189-77- 10 BLISTER PACK in 1 CARTON (68382-189-77) / 10 TABLET, FILM COATED in 1 BLISTER PACK

69584- Oxford Pharmaceuticals, LLC
- 69584-181- Dipyridamole
  - 69584-181-10- 100 TABLET, FILM COATED in 1 BOTTLE (69584-181-10)

69584- Oxford Pharmaceuticals, LLC
- 69584-182- Dipyridamole
  - 69584-182-10- 100 TABLET, FILM COATED in 1 BOTTLE (69584-182-10)

69584- Oxford Pharmaceuticals, LLC
- 69584-183- Dipyridamole
  - 69584-183-10- 100 TABLET, FILM COATED in 1 BOTTLE (69584-183-10)

71205- Proficient Rx LP
- 71205-894- DIPYRIDAMOLE
  - 71205-894-00- 100 TABLET, FILM COATED in 1 BOTTLE (71205-894-00)

71205- Proficient Rx LP
- 71205-894- DIPYRIDAMOLE
  - 71205-894-11- 1000 TABLET, FILM COATED in 1 BOTTLE (71205-894-11)

71205- Proficient Rx LP
- 71205-894- DIPYRIDAMOLE
  - 71205-894-30- 30 TABLET, FILM COATED in 1 BOTTLE (71205-894-30)

71205- Proficient Rx LP
- 71205-894- DIPYRIDAMOLE
  - 71205-894-55- 500 TABLET, FILM COATED in 1 BOTTLE (71205-894-55)

71205- Proficient Rx LP
- 71205-894- DIPYRIDAMOLE
  - 71205-894-60- 60 TABLET, FILM COATED in 1 BOTTLE (71205-894-60)

71205- Proficient Rx LP
- 71205-894- DIPYRIDAMOLE
  - 71205-894-90- 90 TABLET, FILM COATED in 1 BOTTLE (71205-894-90)

71205- Proficient Rx LP
- 71205-895- DIPYRIDAMOLE
  - 71205-895-00- 100 TABLET, FILM COATED in 1 BOTTLE (71205-895-00)

71205- Proficient Rx LP
- 71205-895- DIPYRIDAMOLE
  - 71205-895-11- 1000 TABLET, FILM COATED in 1 BOTTLE (71205-895-11)

71205- Proficient Rx LP
- 71205-895- DIPYRIDAMOLE
  - 71205-895-30- 30 TABLET, FILM COATED in 1 BOTTLE (71205-895-30)

71205- Proficient Rx LP
- 71205-895- DIPYRIDAMOLE
  - 71205-895-55- 500 TABLET, FILM COATED in 1 BOTTLE (71205-895-55)

71205- Proficient Rx LP
- 71205-895- DIPYRIDAMOLE
  - 71205-895-60- 60 TABLET, FILM COATED in 1 BOTTLE (71205-895-60)

71205- Proficient Rx LP
- 71205-895- DIPYRIDAMOLE
  - 71205-895-90- 90 TABLET, FILM COATED in 1 BOTTLE (71205-895-90)

71205- Proficient Rx LP
- 71205-896- DIPYRIDAMOLE
  - 71205-896-00- 100 TABLET, FILM COATED in 1 BOTTLE (71205-896-00)

71205- Proficient Rx LP
- 71205-896- DIPYRIDAMOLE
  - 71205-896-11- 1000 TABLET, FILM COATED in 1 BOTTLE (71205-896-11)

71205- Proficient Rx LP
- 71205-896- DIPYRIDAMOLE
  - 71205-896-30- 30 TABLET, FILM COATED in 1 BOTTLE (71205-896-30)

71205- Proficient Rx LP
- 71205-896- DIPYRIDAMOLE
  - 71205-896-55- 500 TABLET, FILM COATED in 1 BOTTLE (71205-896-55)

71205- Proficient Rx LP
- 71205-896- DIPYRIDAMOLE
  - 71205-896-60- 60 TABLET, FILM COATED in 1 BOTTLE (71205-896-60)

71205- Proficient Rx LP
- 71205-896- DIPYRIDAMOLE
  - 71205-896-90- 90 TABLET, FILM COATED in 1 BOTTLE (71205-896-90)

84206- Tianish Laboratories Private Limited
- 84206-0029-
  - 84206-0029-1- 100 kg in 1 DRUM (84206-0029-1)