Adult Dosing
Mild to moderate pain in adults
- 200 mg PO q4-6 hrs PRN with food
Rheumatoid arthritis
- 400-600 mg PO tid-qid with food
- Max: 3200 mg/day
- Use lowest effective dose, shortest effective treatment duration
Osteoarthritis
- 400-600 mg PO tid-qid with food
- Max: 3200 mg/day
- Use lowest effective dose, shortest effective treatment duration
Pediatric Dosing
- Safety and effectiveness in pediatric patients has not been established
[Outline]
- Fatal/serious cardiovascular thrombotic events, myocardial infarction, and stroke may occur with the therapy; use with caution in patients with cardiovascular disease [US Black Box Warning]
- Therapy is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery [US Black Box Warning]
- Therapy may cause fatal and serious gastrointestinal adverse events including bleeding, ulceration, and perforation of stomach or intestines. Elderly patients are at greater risk for serious gastrointestinal events [US Black Box Warning]
- Therapy can lead to onset of new hypertension or worsening of pre-existing hypertension. Therefore fenoprofen should be used with caution in patients with hypertension. Monitor closely during the initiation and throughout the course of therapy
- Use with caution in patients with fluid retention, compromised cardiac function or heart failure as therapy may cause fluid retention and edema
- Long term use may result in renal papillary necrosis, renal toxicity and other renal injury
- Anaphylactoid reactions may occur in patients without known prior exposure to therapy. Do not give in patients with aspirin triad
- Serious/fatal skin adverse events such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN) may occur with the therapy. Suspend therapy immediately in such conditions
- Therapy may cause premature closure of the ductus arteriosus in the fetus when administered starting at 30-weeks gestation. Therefore use is contraindicated in pregnant woman
- Therapy is associated with visual disturbances. Therefore periodically perform eye examinations during the therapy
- Caution should be exercised by patients whose activities require alertness if they experience CNS side effects while taking fenoprofen
- Periodically perform tests of auditory function during prolonged therapy
- Therapy may cause elevations of ALT or AST. Fatal/severe hepatic reactions, including jaundice and fatal fulminant hepatitis, liver necrosis and hepatic failure have also been reported with the therapy
- Perform hemoglobin or hematocrit check as therapy may cause anemia
- Severe to fatal bronchospasm may occur in patients with aspirin-sensitive asthma
Caution: Use cautiously in
- Renal impairment
- Hepatic impairment
- Cardiovascular disease
- Cardiac disease risk
- HTN
- CHF
- Fluid retention
- GI bleed or PUD history
- Corticosteroid use
- Anticoagulant use
- Coagulation disorder
- Alcohol use
- Smoker
- Elderly or debilitated patients
- Dehydration
- Concurrent diuretics
- ACEI or ARB use
- Asthma
- Prolonged use
Pregnancy Category:C
Breastfeeding: Safety unknown. Because there is little published experience with fenoprofen during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 8 March 2011). Due to the potential for serious adverse reactions in nursing infants, manufacturer recommends discontinuation of nursing or discontinuation of drug, taking into account the importance of the drug to the mother
Pricing data from www.DrugStore.com in U.S.A.
- Nalfon 200 MG CAPS [Bottle] (PEDINOL)
100 mg = $90.39
300 mg = $262.78 - Fenoprofen Calcium 600 MG TABS [Bottle] (MYLAN)
30 mg = $62.69
90 mg = $170.47
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
