- To avoid loss of efficacy of darunavir and to achieve the desired antiviral effect co-administer with ritonavir and food
- Therapy may cause drug induced hepatitis. Monitor AST/ALT in patients with hepatitis, cirrhosis, or elevated transaminase values prior to therapy, especially during the first several months of therapy
- Severe skin reactions, including Stevens-Johnson syndrome reported; fever and increased serum transaminase concentrations also may occur. Discontinue darunavir if severe rash occurs
- Use with caution in patients with a known sulfonamide allergy as it contains a sulfonamide moiety
- Therapy may result in new-onset diabetes mellitus or exacerbation of pre-existing diabetes mellitus and hyperglycemia. Patients may require either initiation or dose adjustments of insulin or oral hypoglycemic agents
- In patients receiving darunavir redistribution or accumulation of body fat, including central obesity, dorsocervical fat enlargement (buffalo hump), peripheral wasting, facial wasting, breast enlargement, and general cushingoid appearance may occur
- In patients with hemophilia type A and B treated with PIs, increased bleeding, including spontaneous skin hematomas and hemarthrosis have been reported
- Post marketing events such as toxic epidermal necrolysis and acute generalized exanthematous pustulosis have been reported with therapy
- Safety and efficacy in pediatric patients <3 years of age have not been established
- Immune reconstitution syndrome may occur in patients treated with combination antiretroviral therapy
Caution: Use cautiously in
- Hepatic impairment
- Hypersensitivity to sulfonamides
- Diabetes mellitus
- Hemophilia
Pregnancy Category:C
Breastfeeding: Unsafe; women with HIV infection should not breastfeed.
Pricing data from www.DrugStore.com in U.S.A.
- Prezista 600 MG TABS [Bottle] (JANSSEN PRODUCTS)
60 mg = $1129.04
180 mg = $3196 - Prezista 400 MG TABS [Bottle] (JANSSEN PRODUCTS)
60 mg = $1086.03
120 mg = $2172.06
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.