Therapeutic Classification: antiretrovirals
Pharmacologic Classification: protease inhibitors, pharmacoenhancers
REMS
Atazanavir
Absorption: Rapidly absorbed (↑ by food).
Distribution: Enters cerebrospinal fluid and semen.
Half-Life: 7 hr.
Cobicistat
Absorption: Absorption follows oral administration.
Distribution: Unknown.
Protein Binding: 9798%.
Half-Life: 34 hr.
(plasma concentrations)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
atazanavir (PO) | rapid | 2.5 hr | 24 hr |
cobicistat (PO) | unknown | 3 hr | 24 hr |
Contraindicated in:
Use Cautiously in:
CV: cardiac conduction abnormalities
Derm: DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), ERYTHEMA MULTIFORME, rash, STEVENS-JOHNSON SYNDROME
EENT: ocular icterus
Endo: Graves' disease, hyperglycemia
GI: autoimmune hepatitis, cholelithiasis, hepatotoxicity, hyperbilirubinemia, jaundice, nausea
GU: nephrolithiasis, new onset/worsening renal impairment
MS: polymyositis
Neuro: Guillain-Barré syndrome
Misc: immune reconstitution syndrome
Drug-drug:
Drug-Natural Products:
Lab Test Considerations: