Usually asymptomatic until the later stages. Symptoms may include visual field defects. Usually bilateral, but can present asymmetrically. Severe field damage and loss of central fixation typically do not occur until late in the disease.
Other
Large fluctuations in IOP, inter-eye IOP asymmetry >5 mm Hg, beta-zone peripapillary atrophy, absence of microcystic corneal edema, and absence of secondary features (e.g., pseudoexfoliation, inflammation).
If anterior chamber angle open on gonioscopy:
If anterior chamber angle closed or partially closed on gonioscopy:
If any of these are present, further evaluation may include:
General Considerations
The decision to treat must be individualized. Some general guidelines are suggested.
Glaucomatous damage is likely if any of the following are present: presence of thin or notched optic nerve rim, characteristic visual field loss, retinal nerve fiber layer damage, or if DDLS score is >5 (see Figure 9.1.2). Treatment should be considered in the absence of manifest damage if IOP is higher than 30 mm Hg, and/or IOP asymmetry is more than 10 mm Hg.
Determine the rate of damage progression by careful follow up. Certain causes of optic nerve rim loss may be static (e.g., prior steroid response). Disc hemorrhages suggest active disease.
The goal of treatment is to enhance or maintain the patients health by halting optic nerve damage while avoiding undue side effects of treatment. The only proven method of stopping or slowing optic nerve damage is reducing IOP. Reduction of IOP by at least 30% appears to have the best chance of preventing further optic nerve damage. An optimal goal may be to reduce the IOP at least 30% below the threshold of progression. If damage is severe, greater reduction in IOP may be necessary.
The main treatment options for glaucoma include medications, laser trabeculoplasty (LT) (selective [SLT] more commonly than argon [ALT]), and glaucoma surgery. Medications or LT are appropriate initial therapies. LT may be especially suitable in patients at risk for poor compliance, with medication side effects, and who have significant trabecular meshwork (TM) pigmentation. Surgery may be appropriate initial treatment if damage is advanced in the setting of a rapid rate of progression or difficult follow up. Options include glaucoma filtering surgery (e.g., trabeculectomy, tube shunt), minimally invasive glaucoma surgery (MIGS), laser cyclophotocoagulation of the ciliary body (e.g., with diode laser or endolaser), and cyclocryotherapy. Surgery should always be considered for any patient with advanced/progressive disease or IOP uncontrolled by other methods.
NOTE: |
MIGS encompasses newer surgical options that offer the advantages of shorter healing times and potentially fewer complications. MIGS is generally considered for patients with mild-to-moderate glaucoma. Some MIGS procedures include trabecular micro-bypass devices, canaloplasty, subconjunctival microstents, deep sclerectomy, endocyclophotocoagulation (ECP), and trabectome trabecular ablation. |
Medications
Unless there are extreme circumstances (e.g., IOP >35 mm Hg or impending loss of central fixation), treatment is often started by using one type of drop in one eye (monocular therapeutic trial) with reexamination in 1 to 6 weeks (depending on IOP and individualized risk factors) to check for efficacy.
NOTE: |
Pilocarpine is not routinely used at Wills Eye due to its adverse side effect profile including associated increased risk for uveitis and retinal detachment, possibility for miosis-induced angle closure, and symptoms such as headache. |
NOTE: |
Patients should be instructed to press a fingertip into the inner canthus to occlude the punctum for 10 seconds after instilling a drop. Doing so will decrease systemic absorption. If unable to perform punctal occlusion, keeping the eyelids closed without blinking for 1 to 2 minutes after drop administration also reduces systemic absorption. |
Argon Laser Trabeculoplasty
In some patients, as previously defined, ALT may be used as first-line therapy. It has an initial success rate of 70% to 80%, dropping to 50% in 2 to 5 years.
Selective Laser Trabeculoplasty
The IOP-lowering effect of SLT is equivalent to ALT. SLT utilizes lower energy and causes less tissue damage, which makes this procedure repeatable.
Guarded Filtration Surgery
Trabeculectomy and tube-shunt surgery may obviate the need for medications. Adjunctive use of antimetabolites (e.g., mitomycin C, 5-fluorouracil) in trabeculectomy surgery may aid in the effectiveness of the surgery but increases the risk of complications (e.g., bleb leaks and hypotony).